Treatment of reactive arthritis involves treating any underlying infection with antibiotics and use of medications such as ibuprofen and acetaminophen to relieve symptoms.
Inflamed joints can be injected with steroids or occasionally the fluid can be drained. If the disease is severe and lasts over a couple of months, doctors may consider using immunosuppressant drugs. Tumor necrosis factor inhibitors may also be effective.
Topical corticosteroids may be useful for treating skin lesions.
Often, rest is required initially to control the pain and physical therapy is also used to maintain a full range of movement of joints.