Autoantibodies

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Common Autoantibodies and Disease Associations

Systemic autoantibodies

The table below includes just some of the more common autoantibodies that are used to identify a variety of systemic autoimmune disorders. These disorders cause inflammatory, arthritis-type symptoms. The table identifies whether each autoantibody test is generally positive with several of these disorders.

Common Systemic Autoantibodies

+ antibody is present in most people with this condition (positive); +/- antibody may or may not be present
Autoantibody	SLE	Sclero-derma	Sjögrens	Dermato-myosistis/ Poly-myositis	Mixed Connective Tissue Disease	RA	Wegener's Granulo-matosis	Celiac Disease
Antinuclear Antibody (ANA)	+	+	+	+/-	+/-	+
Anti-neutrophil Cytoplasmic Antibody (ANCA)							+
Anti-Sjögren’s Syndrome A (Anti-SS-A) (Ro)	+/-		+			+/-
Anti-Sjögren’s Syndrome B (Anti-SS-B) (La)			+			+/-
Cardiolipin autoantibodies	+
Anti-Double Strand DNA (Anti-dsDNA)	+	+/-	+/-		+/-	+/-
Rheumatoid Factor (RF)	+/-	+/-	+/-		+/-	+
Anti-Jo-1				+/-	+/-
Anti-Ribonucleic Protein (Anti-RNP)	+/-	+/-	+		+	+/-
Antiscleroderma Antibody (Anti-SCL-70)			+/-	+/-	+/-
Anti-Smith (Anti-SM)	+		+/-		+/-
Endomysial/ Gliadin Autoantibodies								+

Organ-specific autoantibodies

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