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Breast Cancer Multiparameter Gene Expression Tests

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On This Site
Tests: Estrogen/Progesterone Receptor Status, BRCA-1 and BRCA-2, HER2/neu, Tumor Markers
Conditions: Breast Cancer
Features: The Universe of Genetic Testing

Elsewhere On The Web
National Cancer Institute: Breast Cancer
Centers for Disease Control and Prevention: Breast Cancer
American Cancer Society: Detailed Guide, Breast Cancer
Breastcancer.org: Breast Cancer Tests: Screening, Diagnosis and Monitoring 
Mayo Clinic: Recurrent breast cancer: Risk factors 
Life After early Breast Cancer: Risk of Breast Cancer Recurrence 

Article Sources

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Moynihan, T. (2012 July 10). Gene expression profiling for breast cancer: What is it? Mayo Clinic [On-line information]. Available online at http://www.mayoclinic.com/health/gene-expression-profiling/AN02081 through http://www.mayoclinic.com. Accessed January 2013.

(Reviewed 2011 October 21). Genetic Testing, Health Professionals: More About the EGAPP™ Tumor Gene Expression Profiling To Predict Risk of Breast Cancer Recurrence Recommendation. CDC [On-line information]. Available online at http://www.cdc.gov/genomics/gtesting/EGAPP/recommend/GEP_provider.htm through http://www.cdc.gov. Accessed January 2013.

(Reviewed 2012 August 23). Breast Cancer. American Cancer Society [On-line information]. Available online at http://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-diagnosis through http://www.cancer.org. Accessed January 2013.

EGAPP Working Group (2009 January). Recommendations from the EGAPP Working Group: can tumor gene expression profiling improve outcomes in patients with breast cancer? Genetics in Medicine v 11(1) [On-line information]. PDF available for download at http://www.egappreviews.org/docs/EGAPPWG-BrCaGEPRec.pdf through http://www.egappreviews.org. Accessed January 2013.

National Comprehensive Cancer Network. Guidelines for patients, Breast cancer (version 2, 2011). Available online at http://www.nccn.com/files/cancer-guidelines/breast/index.html#/22/ through http://www.nccn.com. Accessed January 2013.

(©2011) Mammaprint, Breast Cancer Recurrence Assay. Agendia. Available online at http://www.agendia.com/pages/mammaprint/21.php through http://www.agendia.com. Accessed January 2013.

Sources Used in Previous Reviews

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 198-199.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. 243-244.

Harris, L. et. al. (2007 November 20). American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer. Journal of Clinical Oncology v25(33) [On-line journal article]. Available online at http://jco.ascopubs.org/cgi/reprint/JCO.2007.14.2364v1 through http://jco.ascopubs.org. Accessed on 12/9/07.

(2007 May 14). Test Determines Risk of Breast Cancer Returning. FDA Consumer Update [On-line information]. Available online at http://www.fda.gov/consumer/updates/breastcan051407.html through http://www.fda.gov. Accessed on 12/9/07.

(© 2007). Oncotype DX FAQ. Genomic Health [On-line information]. Available online at http://www.genomichealth.com/oncotype/faq/hcp.aspx through http://www.genomichealth.com. Accessed on 12/9/07.

(© 2007). About Oncotype DX. Genomic Health [On-line information]. Available online at http://www.genomichealth.com/oncotype/about/hcp.aspx through http://www.genomichealth.com. Accessed on 12/9/07.

FDA clears MammaPrint test for marketing. News-Medical.Net [On-line information]. Available online at http://www.news-medical.net/?id=21736 through http://www.news-medical.net. Accessed on 12/9/07.

Detailed Guide: Breast Cancer. American Cancer Society [On-line information]. Available online at http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?dt=5 through http://www.cancer.org. Accessed on 12/9/07.

Barr, H. et. al. (2007 May 31). Breast Cancer Module I: Breast Anatomy, Physiology, and Pathology CME/CE. Medscape CME [On-line information]. Available online at http://www.medscape.com/viewarticle/548921 through http://www.medscape.com. Accessed on 12/9/07.

(2007 October 10). Breast Cancer Statistics. CDC [On-line information]. Available online at http://www.cdc.gov/cancer/breast/statistics/%20 through http://www.cancer.org. Accessed on 6/8/08.

(2008 June 2). Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores. Genomic Health [On-line Press Release]. Available online at http://investor.genomichealth.com/ReleaseDetail.cfm?ReleaseID=313338 through http://investor.genomichealth.com. Accessed on 6/8/08.

(2006 December). Breast Cancer Gene Expression Ratio (HOXB13:IL17BR). Quest Diagnostics, Nichols Institute [On-line information]. PDF available for download at http://www.nicholsinstitute.com/HematologyOncology/BreastCancerCombo.pdf through http://www.nicholsinstitute.com. Accessed on 6/8/08.

Cancer of the Breast. NCI, Surveillance Epidemiology and End Results Stat Fact Sheets [On-line information]. Available online at http://seer.cancer.gov/statfacts/html/breast.html through http://seer.cancer.gov. Accessed on 6/8/08.

(2006 May 23). The TAILORx Breast Cancer Trial. NCI [On-line information]. Available online at http://www.cancer.gov/clinicaltrials/digestpage/TAILORx through http://www.cancer.gov. Accessed on 6/1/08.

(2006 May 23). Personalized Treatment Trial for Breast Cancer Launched. NCI [On-line information]. Available online at http://www.cancer.gov/newscenter/pressreleases/TAILORxRelease through http://www.cancer.gov. Accessed on 6/1/08.

(2008 February 29). New Study of Targeted Therapies for Breast Cancer Establishes Model for Global Clinical Trials. NCI [On-line information]. Available online at http://www.cancer.gov/newscenter/pressreleases/ALTTO through http://www.cancer.gov. Accessed on 6/1/08.

Vachani, C. (2007). Predicting Cancer Recurrence. OncoLink [On-line information]. Available online at http://www.oncolink.org/resources/article.cfm?c=16&s=59&ss=224&id=932 through http://www.oncolink.org. Accessed on 6/1/08.

Marchionni, L. et. al. (2008 March 4). Annals of Internal Medicine [On-line information]. Available online at http://www.annals.org/cgi/content/full/0000605-200803040-00208v1 through http://www.annals.org. Accessed on 6/1/08.

Gregory J. Tsongalis, Ph.D., HCLD, FACB. Director, Molecular Pathology, Co-Director, Pharmacogenomics Program, Associate Professor of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH.

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