Genetic Tests for Targeted Cancer Therapy

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Articles: Universe of Genetic Testing
In the News: Beneficiaries of New Melanoma Drug Identified by Genetic Testing (2011)

Elsewhere On The Web
Association for Molecular Pathology  
American Cancer Society: Targeted Therapy  
National Cancer Institute: Targeted Cancer Therapies  
American Cancer Society: Lung Cancer (Non-Small Cell)  
National Cancer Institute: General Information About Non-Small Cell Lung Cancer (NSCLC)  
American Cancer Society: Gastrointestinal Stromal Tumor (GIST)  
National Cancer Institute: Colon and Rectal Cancer  
American Cancer Society: Colorectal Cancer Early Detection 

Article Sources

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Linnea Baudhuin, Phd, DABMG. Assistant Professor of Laboratory Medicine. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

(Revised 2011 November 18). Targeted Cancer Therapies. National Cancer Institute Fact Sheet [On-line information]. Available online at http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted through http://www.cancer.gov. Accessed March 2012.

Gaughan, E. and Costa, D. (2011 May 19). Genotype-driven Therapies for Non-small Cell Lung Cancer, Focus on EGFR, KRAS and ALK Gene Abnormalities. Medscape Today News from Ther Adv Med Oncol v 3(3):113-125 [On-line information]. Available online at http://www.medscape.com/viewarticle/742530 through http://www.medscape.com. Accessed March 2012.

Ribas, A. and Flaherty, K. (2011 July 8). BRAF Targeted Therapy Changes the Treatment Paradigm in Melanoma. Nat Rev Clin Onc. 2011;8(7) © Medscape Today News from Nat Rev Clin Onc. v 8(7) [On-line information]. Available online at http://www.medscape.com/viewarticle/744864 through http://www.medscape.com. Accessed March 2012.

Mahadevan, D. and Talavera, F. (2011 May 16) Targeted Cancer Therapy. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1372666-overview#showall through http://emedicine.medscape.com. Accessed March 2012.

Bayon, R. and Chaturvedi, P. (2011 March 29). Targeted Molecular Therapy in Head and Neck Squamous Cell Carcinoma Overview of Targeted Molecular Therapy in HNSCC. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/854971-overview through http://emedicine.medscape.com. Accessed March 2012.

(2009 July/August). KRAS Mutation Testing for Anti-Epidermal Growth Factor Receptor Therapy in Colorectal and Lung Cancer. Mayo Clinic Mayo Medical Laboratory Communique [On-line information]. Available online at http://www.mayomedicallaboratories.com/articles/communique/2009/07.html through http://www.mayomedicallaboratories.com. Accessed May 2012.

Cankovic, M. et. al. (2009 December 8). Clinical Performance of JAK2 V617F Mutation Detection Assays in a Molecular Diagnostics Laboratory: Evaluation of Screening and Quantitation Methods. American Journal of Clinical Pathology v 132(5):713-721. [On-line information]. Available online at http://www.medscape.com/viewarticle/712654 through http://www.medscape.com. Accessed March 2012.

(Updated 2011 July 8). Colorectal Cancer Trials Support Gene Testing for Two Drugs. National Cancer Institute Fact Sheet [On-line information]. Available online at http://www.cancer.gov/clinicaltrials/results/summary/2008/genetest1108 through http://www.cancer.gov. Accessed March 2012.

Cheson, B. et. al. (2011 November 23). 2011 Top Game Changers in Oncology. Medscape Today News [On-line information]. Available online at http://www.medscape.com/viewarticle/754136 through http://www.medscape.com. Accessed March 2012.

Corless, C. et. al. (2011 December 31). Gastrointestinal Stromal Tumours Origin and Molecular Oncology. Medscape Today News from Nat Rev Cancer v 11(12):865-878 [On-line information]. Available online at http://www.medscape.com/viewarticle/754503 through http://www.medscape.com. Accessed March 2012.

Markman, M. (Updated 2011 November 29). Genetics of Non-Small Cell Lung Cancer. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1689988-overview through http://emedicine.medscape.com. Accessed March 2012.

Cook, J. et. al. (Updated 2011 July). Gastrointestinal Stromal Tumors – GIST. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/GIST.html?client_ID=LTD through http://www.arupconsult.com. Accessed March 2012.

Lyon, E. et. al. (Updated 2011 July). 5-Fluorouracil Sensitivity. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/5FU.html through http://www.arupconsult.com. Accessed March 2012.

Lyon, E. et. al. (Updated 2011 April). UGT1A1 Genotyping – Irinotecan. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Irinotecan.html through http://www.arupconsult.com. Accessed March 2012.

Turner, J. et. al. (2010 December 17). KRAS Mutation Testing for Colorectal Cancer (CRC). CAP [On-line information]. Available online through http://www.cap.org. Accessed March 2012.

Test ID: FLCA Lung Cancer, ALK (2p23) Rearrangement, FISH, Tissue. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/60619 through http://www.mayomedicallaboratories.com. Accessed March 2012.

Lyon, E. et. al. (Updated 2011 April). CYP2D6 Genotyping – Tamoxifen. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Tamoxifen.html through http://www.arupconsult.com. Accessed March 2012.

Jarboe, E. et. al. (Updated 2011 February). Colorectal Cancer. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/ColorectalCancer.html#tabs=0 through http://www.arupconsult.com. Accessed March 2012.

Johnson-Davis, K. and McMillin, G. (Updated 2011 August). Pharmacogenetics – PGx. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/PGx.html?client_ID=LTD#tabs=0 through http://www.arupconsult.com. Accessed March 2012.

Kelland, K. (2012 March 7). Cancer gene mutation more complex than previously thought: study. MedlinePlus from Reuters Health [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/news/fullstory_122697.html through http://www.nlm.nih.gov. Accessed March 2012.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 602-603

(©2012) American Cancer Society. Treatment Types. Available online at http://www.cancer.org/Treatment/TreatmentsandSideEffects/TreatmentTypes/index through http://www.cancer.org. Accessed April 2012.

(©2012) American Cancer Society. Targeted Therapy. Available online at http://www.cancer.org/Treatment/TreatmentsandSideEffects/TreatmentTypes/TargetedTherapy/index through http://www.cancer.org. Accessed April 2012.

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