Protein Groups

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Also known as: Serum Protein Electrophoresis; Protein ELP; SPE; SPEP; Urine Protein Electrophoresis; UPE; UPEP; IFE; CSF Protein Electrophoresis
Formal name: Protein Electrophoresis; Immunofixation Electrophoresis

Additional Information on Electrophoresis

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Protein Groups

Major plasma proteins and their functions listed according to their electrophoretic group
group protein function
Albumin Albumin Main plasma protein; reduces tissue water accumulation, transports many substances
Alpha1-globulin
Alpha1-Antitrypsin Inactivates trypsin and other proteolytic enzymes, reduces damage from inflammation
Orosomucoid (Alpha-1-acidic glycoprotein)
Immune response modifier, binds acidic drugs such as lidocaine
High Density Lipoprotein (HDL)
Reverse transport of cholesterol ("good cholesterol")
Alpha2-globulin Alpha2-Macroglobulin Binds to and inactivates enzymes, preventing tissue damage
Haptoglobin Hemoglobin-binding protein
Ceruloplasmin Copper-containing enzyme, involved in normal iron metabolism
Beta-globulin Transferrin Iron transport and delivery to cells
Low Density Lipoprotein (LDL) Cholesterol delivery to tissue
Complement component 3 Helps regulate inflammatory response to foreign substances
Gamma-globulin    IgA
Immunoglobulin involved in secretions
IgG Major immunoglobulin; long term immunity
IgM Initial response immunoglobulin
C-reactive protein Inflammatory response mediator
Fibrinogen Coagulation factor (found only in plasma, not serum)