1. What signs and symptoms are seen with deficient GH and IGF-1?
In children, the following may indicate GH and/or IGF-1 deficiency:
Slowed growth rate in early childhood relative to group normsShorter stature than others of the same chronological ageDelayed pubertyx-rays showing delayed bone development.
In adults, abnormally low levels of GH and/or IGF-1 may cause subtle, nonspecific symptoms such as:Decreased bone densityFatigueAdverse lipid changesReduced exercise tolerance.
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2. What signs and symptoms are seen with excess GH and IGF-1 production?
In a child, it is unusual tallness that is often first noticed. With an adult, it may be more subtle: a larger nose, thicker lips, a more prominent jaw, or rings and shoes that no longer fit. Other
signs and
symptoms may include:
Deepened, husky voice
Enlarged organs - liver, heart, kidneys, and spleen
Enlarged tongue
Erectile dysfunction
Fatigue
Headaches and visual disturbances
Joint pain and swelling
Menstrual cycle irregularities
Muscle weakness
Snoring
Sweating and body odor
Thickening of the skin, skin tags
Trapped nerves (Carpal tunnel syndrome)^ Back to top
3. How long do I have to be monitored?
As long as you are considered to have abnormal (low or high) GH production or are receiving GH replacement therapy, your IGF-1 will need to be monitored.
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