The test is used to screen symptomatic newborns and infants for cystic fibrosis and to evaluate both children and adults for pancreatic insufficiency.

The trypsin/chymotrypsin test is easy and noninvasive. It is used as a screen for cystic fibrosis and pancreatic function. It is done when a newborn or infant has symptoms of cystic fibrosis such as persistent diarrhea, foul-smelling bulky greasy stools, malnutrition, and vitamin deficiency. It is also ordered when a child or an adult has these symptoms, in order to help diagnose pancreatic insufficiency.

A positive result is normal, indicating the presence of trypsin and chymotrypsin in the stool. A negative result is not diagnostic, but it does indicate that further testing, both for pancreatic insufficiency and for cystic fibrosis, may be indicated. Other pancreas dysfunctions, such as acute and chronic pancreatitis, can cause negative results.

If someone's pancreas is not functioning correctly, the individual will need to be monitored closely by his physician. He may find symptom relief and nutritional improvement by taking doctor-prescribed oral enzymes and vitamin supplements.