Although there is no cure for ankylosing spondylitis, exercise and physical therapy can help prevent joint stiffness and certain medications can relieve pain and inflammation. These include non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, and indomethacin. Other treatments include disease-modifying antirheumatic drugs (DMARDs) such as methotrexate or sulfasalazine, and corticosteroids like prednisone. Newer drugs include adalimumab, etanercept and infliximab, which are tumor necrosis factor (TNF) blockers. All of these drugs, however, are associated with side-effects and the treatment options should be carefully reviewed with your doctor.