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Antiphospholipid Syndrome

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Signs and Symptoms

The symptoms associated with APS will vary from person to person and with each thrombotic episode. With pregnant women, APS may cause recurrent miscarriages, pre-eclampsia, and premature births but no distinguishable symptoms. Symptoms associated with a blood clot depend upon where the clot forms in the body and damage that occurs. APS signs and symptoms may include:

  • Persistent headaches
  • Chest pain
  • Shortness of breath
  • Nausea
  • Speech and/or cognitive changes
  • Seizures
  • Redness, swelling, and pain in a leg or arm
  • A red lacy rash on the arms or legs (livedo reticularis)
  • Skin ulcers
  • Mild to severe bleeding (with significant thrombocytopenia)

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