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Bleeding Disorders
Platelet deficiency (thrombocytopenia) or dysfunction

Inherited
A variety of other rare inherited conditions may cause platelet disorders.

Acquired

  • Bone marrow not producing enough platelets
  • Immune thrombocytopenic purpura (ITP), autoimmune disease; may go away on its own
  • Drugs such as quinine, sulfa antibiotics, and gold salts may decrease number of platelets.
  • Drugs such as aspirin and nonsteroidal anti-inflammatory drugs may cause dysfunctional platelets.
  • Disease-related: HIV, liver disease, kidney failure, leukemia, multiple myeloma, cirrhosis of the liver, and systemic lupus erythematosus may all cause decreased platelet counts
  • Massive blood replacement (platelet survival is limited in stored blood)
  • Cardiopulmonary bypass surgery (platelets are activated and become deficient and dysfunctional)


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    This article last reviewed on September 7, 2007.
     
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