Signs and Symptoms
Signs and symptoms associated with hemoglobin variants can vary in type and severity depending on the variant present and whether an individual has one variant or a combination. Some are the result of an increase in the breakdown (hemolysis) of red blood cells and a shortened RBC survival, leading to anemia. Some examples include:
- Weakness, fatigue
- Lack of energy
- Jaundice
- Pale skin (pallor)
Some serious signs and symptoms include:
- Episodes of severe pain
- Shortness of breath
- Enlarged spleen
- Growth problems in children
- Upper abdomen pain (due to stone formation in gallbladder)
