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Excessive Clotting Disorders

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Conditions: Heart Attack, Stoke, Liver Disease, Lupus, Antiphospholipid Syndrome, Kidney Disease, Vasculitis,  DIC

Elsewhere On The Web
National Alliance for Thrombosis & Thrombophilia (NATT)
National Heart, Lung and Blood Institute: Excessive Clotting, Deep Vein Thrombosis, Pulmonary Embolism
American Academy of Family Physicians: Excessive Blood Clotting, DVT  
Clot Care Online Resources 
Mayo Clinic: Blood Clots 
American Society of Hematology: Blood Clots

Article Sources

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 770-775.

(June 9, 2009) Centers for Disease Control and Prevention. Thrombophilia, Clotting Disorders. Available online at http://www.cdc.gov/ncbddd/hbd/clotting.htm through http://www.cdc.gov. Accessed May 2011.

(©2006) National Hemophilia Foundation. What are clotting disorders? Available online at http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=176&contentid=378 through http://www.hemophilia.org. Accessed May 2011.

(May 2010) American Academy of Family Physicians. Hypercoagulation: Excessive Blood Clotting. Available online at http://familydoctor.org/online/famdocen/home/common/blood/244.html through http://familydoctor.org. Accessed May 2011.

Cushman M. Inherited Risk Factors for Venous Thrombosis. American Society of Hematology. Hematology 2005. Available online at http://asheducationbook.hematologylibrary.org/cgi/content/full/2005/1/452 through http://asheducationbook.hematologylibrary.org. Accessed May 2011.

(January 12, 2010) Spence R. Hematologic Disorders, Non-platelet. eMedicine article. Available online at http://emedicine.medscape.com/article/210467-overview through http://emedicine.medscape.com. Accessed May 2011.

(January 5, 2011) Schick P. Hypercoagulability - Hereditary Thrombophilia and Lupus Anticoagulants Associated With Venous Thrombosis and Emboli. eMedicine article. Available online at http://emedicine.medscape.com/article/211039-overview throughhttp://emedicine.medscape.com. Accessed May 2011.

Anderson J, Weitz J.  Hypercoagulable States. Clin Chest Med. 2010; 31(4):659-73. Available online at http://www.medscape.com/medline/abstract/21047574 through http://www.medscape.com. Accessed May 2011.

(©2011) ARUP Laboratories. Hyperocoagulable states, Thrombophilia. Available online at http://www.arupconsult.com/Topics/Thrombophilia.html?client_ID=LTD through http://www.arupconsult.com. Accessed May 2011.

(©2011) Mayo Medical Laboratories. Thrombophilia Profile. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83093 through http://www.mayomedicallaboratories.com. Accessed May 2011.

(May 11, 2011) Patel K, et al. Deep Vein Thrombosis. eMedicine article. Available online at http://emedicine.medscape.com/article/1911303-overview through http://emedicine.medscape.com. Accessed May 2011.

(June 11, 2009) Cuker E. Protein C Deficiency. Medscape Reference. Available online at http://emedicine.medscape.com/article/205470-clinical#a0218 through http://emedicine.medscape.com. Accessed June 2011.

(August 27, 2009) Godwin J. Protein S Deficiency. Medscape Reference. Available online at  http://emedicine.medscape.com/article/205582-overview through http://emedicine.medscape.com. Accessed June 2011.

(©NBCA 2009) Moll S. Antithrombin Deficiency, An In-depth Guide for Patients and Healthcare Providers. National Blood Clot Alliance. Available online at http://stoptheclot.org/News/article138.htm through http://stoptheclot.org. Accessed June 2011. 

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Coagulation Test Panels. Clinical and Research Laboratories, Florida Hospital Cancer Institute [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm through http://www.fhci-labs.com.

Ryan, D. (2003 January). Platelet Function Testing. Strong Health Clinical Laboratories Newsletter, Vol. 28, No. 1 [On-line newsletter]. Available online at http://www.urmc.rochester.edu/path/newsletter103.htm through http://www.urmc.rochester.edu.

Laposata, M. & Vancott, E. (2000 January). How to work up hypercoagulability. CAP In the News [On-line Coagulation Case Study]. Available online at http://www.cap.org/CAPToday/casestudy/coag5.html through http://www.cap.org.

Bleeding Disorders. The Merck Manual of Medical Information-Home Edition, Section 14. Blood Disorders, Chapter 155 [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual_home/sec14/155.jsp through http://www.merck.com.

Venomous Bites and Stings. The Merck Manual of Medical Information-Home Edition, Section 24. Accidents and Injuries, Chapter 287 [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual_home/sec24/287.jsp through http://www.merck.com.

Lee, D. (2000 July 24). Platelet Aggregometry. Stanford Interventional Cardiology [On-line information]. Available online at http://cvmed.stanford.edu/interventional/aggregometry.htm through http://cvmed.stanford.edu.

Cortese Hassett, A. (2002). Platelet Function Testing. Transfusion Medicine Update, The Institute for Transfusion Medicine, Issue #5 [On-line information]. Available online at http://www.itxm.org/TMU2002/Issue5.htm through http://www.itxm.org.

Menta, S. (1999 Spring). The Coagulation Cascade. Physiology Disorders Evaluation, College of Medicine, Univ of Florida [On-line information]. Available online at http://www.medinfo.ufl.edu/year2/coag/title.html through http://www.medinfo.ufl.edu.

Elstrom, R. (2001 November 10, Updated). Factor X assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003680.htm.

Elstrom, R. (2001 November 10, Updated). Factor II assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003674.htm.

Elstrom, R. (2001 November 10, Updated). Factor II deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000549.htm.

Elstrom, R. (2001 November 10, Updated). Factor IX assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003679.htm.

Elstrom, R. (2001 October 6, Updated). Hemophilia B. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000539.htm.

Elstrom, R. (2001 November 10, Updated). Factor V assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003675.htm.

Elstrom, R. (2002 May 6, Updated). Factor V deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000550.htm.

Elstrom, R. (2001 October 28, Updated). Platelet aggregation test. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003669.htm.

Elstrom, R. (2001 November 25, Updated). Fibrinogen. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003650.htm.

Elstrom, R. (2001 November 13, Updated). Antithrombin III. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003661.htm.

Elstrom, R. (2001 October 28, Updated). Protein S. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003660.htm.

Elstrom, R. (2001 October 9, Updated). Factor VIII assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003678.htm.

Elstrom, R. (2001 October 14, Updated). Factor X deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000553.htm.

Elstrom, R. (2001 October 14, Updated). Factor XII (Hageman factor) deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000545.htm.

Elstrom, R. (2001 November 10, Updated). Factor XII assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003681.htm.

Elstrom, R. (2001 November 25, Updated). PT. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm.

Elstrom, R. (2001 October 28, Updated). Protein C. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003659.htm.

Elstrom, R. (2001 November 25, Updated). PTT. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm.

Elstrom, R. (2001 November 3, Updated). Fibrin degradation products. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003655.htm.

Elstrom, R. (2001 October 21, Updated). Bleeding disorders. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/001304.htm.

Elstrom, R. (2001 November 10, Updated). Factor VII assay. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003676.htm.

Elstrom, R. (2001 October 14, Updated). Factor VII deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000548.htm.

Matsui, W. (2002 May 5, Updated). Primary or secondary fibrinolysis. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000577.htm.

Matsui, W. (2002 February 2, Updated). Congenital antithrombin III deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000558.htm.

Kovacs, B. (2001 November 26, Updated). Systemic lupus erythematosus. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm.

What is a Bleeding Disorder?, History. National Hemophilia Foundation, Bleeding Disorders Info Center [On-line information]. Available online at http://www.hemophilia.org/bdi/bdi_history.htm through http://www.hemophilia.org.

What is a Bleeding Disorder? National Hemophilia Foundation, Bleeding Disorders Info Center [On-line information]. Available online at http://www.hemophilia.org/bdi/bdi_general.htm through http://www.hemophilia.org.

Hemophilia A (Factor VIII Deficiency). National Hemophilia Foundation, Bleeding Disorders Info Center [On-line information]. Available online at http://www.hemophilia.org/bdi/bdi_types1.htm through http://www.hemophilia.org.

Bauer, K. (2001). The Thrombophilias: Well-Defined Risk Factors with Uncertain Therapeutic Implications. Ann Intern Med. 2001;135:367-373 [Journal]. Available online through http://www.annals.org.

DeLoughery, T. (1999 March 15). Tests of Hemostasis and Thrombosis. OHSU [Online student handout]. Available online at http://www.ohsu.edu/som-hemonc/handouts/deloughery/printtest.html through http://www.ohsu.edu.

Coagulation Test Panels. Clinical and Research Laboratories, Florida Hospital Cancer Institute [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm through A href="http://www.fhci-labs.com">http://www.fhci-labs.com.

Ryan, D. (2003 January). Platelet Function Testing. Strong Health Clinical Laboratories Newsletter, Vol. 28, No. 1 [On-line newsletter]. Available online at http://www.urmc.rochester.edu/path/newsletter103.htm through http://www.urmc.rochester.edu.

American Cancer Society (July 2003). Heparin a Better Choice for Cancer Patients with Clots. (Online information, accessed April 2007). Available online through http://www.cancer.org.

Bren, L, U.S. FDA Consumer Magazine (Nov-Dec 2004). Avoid Deep Vein Thrombosis: Keep the Blood Flowing. (Accessed April 2007). Available online at http://www.fda.gov/fdac/features/2004/604_vein.html through http://www.fda.gov.

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