Multiple Myeloma

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Tests: Complete Blood Count, Comprehensive Metabolic Panel, BUN, Creatinine, Tumor Markers, Protein Electrophoresis, Uric Acid, Calcium, Bone Marrow Aspiration and Biopsy, Beta-2 Microglobulin, Quantitative Immunoglobulins, Serum Free Light Chains
Conditions: Bone Marrow Disorders, Proteinuria

Elsewhere On The Web
American Society of Hematology: Myeloma 
College of American Pathologists: Multiple Myeloma 
American Academy of Family Physicians: Multiple Myeloma 
Multiple Myeloma Research Foundation
The International Myeloma Foundation
National Cancer Institute: What You Need to Know About Multiple Myeloma 
American Cancer Society: Multiple Myeloma
Mayo Clinic: Monoclonal Gammopathy of Undetermined Significance 
National Comprehensive Cancer Network: Multiple Myeloma Guidelines for Patients 
American Society of Clinical Oncology: Multiple Myeloma 

Article Sources

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

(Reviewed January 15, 2013) American Cancer Society. Multiple Myeloma, Detailed Guide. Available online at http://www.cancer.org/cancer/multiplemyeloma/detailedguide/index through http://www.cancer.org. Accessed June 2013.

(Reviewed May 17, 2013) National Cancer Institute. Multiple Myeloma/Plasma Cell Dyscrasia. Available online at http://www.cancer.gov/cancertopics/types/myeloma through http://www.cancer.gov. Accessed June 2013.

(January 31, 2012) American Cancer Society. Waldenstrom's Macroglobulinemia, Detailed Guide. Available online at http://www.cancer.org/cancer/waldenstrommacroglobulinemia/detailedguide/waldenstrom-macroglobulinemia-w-m through http://www.cancer.org. Accessed June 2013.

(Updated June 3, 2013) Seiter K. Multiple Myeloma. Medscape Reference. Available online at http://emedicine.medscape.com/article/204369-overview through http://emedicine.medscape.com. Accessed June 2013.

(©2013) The Multiple Myeloma Research Foundation. What is Multiple Myeloma? Available online at http://www.themmrf.org/living-with-multiple-myeloma/newly-diagnosed-patients/what-is-multiple-myeloma/ through http://www.themmrf.org. Accessed June 2013.

(May 20, 2013) Terpos E, et al. International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma–Related Bone Disease. Journal of Clinical Oncology. Published online before print May 20, 2013, doi: 10.1200/JCO.2012.47.7901.

(2012) National Comprehensive Cancer Network. Multiple Myeloma Guidelines for Patients. Available online at http://www.nccn.org/patients/patient_guidelines/myeloma/index.html#/12/ through http://www.nccn.org. Accessed June 2013.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

(2003 April, Updated) Multiple Myeloma: What It Is and How It's Treated. Familydoctor.org [On-line information]. Available online at http://familydoctor.org/x2030.xml through http://familydoctor.org.

(2002 September 16, Updated). What you need to know about Multiple Myeloma. National Cancer Institute [On-line information]. Available online at http://www.nci.nih.gov/cancerinfo/wyntk/myeloma through http://www.nci.nih.gov.

Plasma Cell Disorders, Introduction. The Merck Manual Second Home Edition, Section 14, Chapter 175: Plasma Cell Disorders [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual_home2/sec14/ch175/ch175a.jsp through http://www.merck.com.

(2003 June 11). Multiple Myeloma. American Cancer Society [On-line information]. PDF available for download at http://www.cancer.org/docroot/CRI/content/CRI_2_4_7x_CRC_Multiple_Myeloma_PDF.asp through http://www.cancer.org.

(© 2005) Bence-Jones Protein, Quantitative. ARUPs Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a111.jsp#1145216 through http://www.aruplab.com.

Lonial, S. (2005 September 9, Reviewed). About Myeloma, Diagnosis and Staging. Multiple Myeloma Research Foundation [On-line information]. Available online at http://www.multiplemyeloma.org/about_myeloma/2.05.asp through http://www.multiplemyeloma.org.

Keren, D. (1999). Consensus Guidelines for Evaluating Monoclonal Gammopathies. Warde Report, 1999 v(10):1 [On-line information]. Available online at http://www.wardelab.com/arc_3.html through http://www.wardelab.com.

(Reviewed Feb 13, 2009) American Cancer Society. Detailed Guide: Multiple Myeloma. Available online at http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?rnav=cridg&dt=30 through http://www.cancer.org. Accessed March 2009.

Lonial S. Multiple Myeloma Research Foundation, Intro to Myeloma. Available online at http://www.multiplemyeloma.org/about_myeloma/index.php through http://www.multiplemyeloma.org. Accessed March 2009.

(January 10, 2009) Mayo Clinic. Multiple Myeloma. Available online at http://www.mayoclinic.com/health/multiple-myeloma/DS00415 through http://www.mayoclinic.com. Accessed March 2009.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson RA and Pincus MR, eds. Philadelphia: 2007. P. 576.

(July 20, 2006) Hill P, Forsyth J, Rai B, Mayne S. Serum Free Light Chains: An Alternative to the Urine Bence Jones Proteins Screening Test for Monoclonal Gammopathies. Clinical Chemistry. 2006;52:1743-1748.

(2006) International Myeloma Foundation. Understanding Serum Free Light Chain Assays. PDF available for download at http://myeloma.org/pdfs/UnderstandingFreeLight.pdf through http://myeloma.org. Accessed March 2009.

(October 31, 2006) van Hoeven K. Serum Free Light Chain Assays for the Diagnosis and Monitoring of Multiple Myeloma and Other Monoclonal Gammopathies. Presentation PDF available for download through http://www.aacc.org. Accessed March 2009.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. P. 207-209.

Harrison's Principles of Internal Medicine. 16th ed. Kasper D, Braunwald E, Fauci A, Hauser S, Longo D, Jameson JL, eds. McGraw-Hill, 2005. Pp. 658-659.

Rajkumar S V. MGUS and Smoldering Multiple Myeloma: Update on Pathogenesis, Natural History, and Management. Hematology Jan 2005; 2005: 340-345. Available online at http://asheducationbook.hematologylibrary.org/cgi/content/full/2005/1/340#R6 through http://asheducationbook.hematologylibrary.org. Accessed May 2009.

Kyle, Robert A., Therneau, Terry M., Rajkumar, S. Vincent, Offord, Janice R., Larson, Dirk R., Plevak, Matthew F., Melton, L. Joseph, III. A Long-Term Study of Prognosis in Monoclonal Gammopathy of Undetermined Significance. N Engl J Med 2002 346: 564-569. Available online at http://content.nejm.org/cgi/content/full/346/8/564 through http://content.nejm.org. Accessed May 2009.

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