Neural Tube Defects
The goals with treatment are to prevent as many cases of NTDs as possible. For those affected, the goals are to minimize symptoms and complications and to lead as normal and active a life as possible. Treatments must be tailored to the individual, and new options are constantly emerging. Patients and their parents should work with their doctors to determine what treatments are right for them.
Adequate folate/folic acid is the primary prevention tool. Recent evidence suggests that folic acid supplementation could reduce the incidence of NTDs by up to 70%, but the protection it provides must be in place at the time of conception. It is recommended that all women of childbearing age get at least 400 micrograms of folic acid/folate a day. Since folic acid is a water-soluble vitamin, it must be constantly replenished. Folic acid can be found in dark green vegetables and some fruit. Most grain products in the U.S. are good sources because they have been fortified with added folic acid. Women who have spina bifida, or who already have a child with spina bifida, or who are otherwise considered at an increased risk of having a baby with an NTD may be given a prescription for about 10 times the recommended dose for several months before becoming pregnant. This higher dose is not recommended, however, for the general population.
