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Sjögren Syndrome

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Tests

Tests for Sjögren syndrome may include:

  • Antinuclear antibodies (ANA) — positive in most cases
  • Rheumatoid factor (RF) — may be positive
  • Antibodies more specific to Sjögren syndrome — Anti-SS-A (also called Ro) and Anti-SS-B (also called La); the tests for these antibodies are often performed as part of an ENA panel and are frequently positive.

Other tests:

  • Salivary gland biopsy — to look for accumulation of lymphocytes and inflammation
  • Schirmer test — to measure tear production
  • Rose Bengal or lissamine green staining of eye (cornea or conjunctiva) — to evaluate the extent to which dryness has damaged the surface of the eye

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