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Vitamin B12 Deficiency and Folate Deficiency

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Symptoms

The symptoms associated with B12 and folate deficiency are initially subtle and nonspecific. They are related to the resulting macrocytic anemia, nerve involvement, and gastrointestinal changes. People with an early deficiency may be diagnosed before they experience any overt symptoms. Other affected people may experience a variety of mild to severe symptoms that can include:

  • Diarrhea
  • Dizziness
  • Fatigue, weakness
  • Loss of appetite
  • Malabsorption
  • Paleness
  • Rapid heart rate
  • Shortness of breath
  • Sore tongue and mouth
  • Tingling, numbness, and/or burning in the feet, hands, arms, and legs (with B12)
  • Confusion
  • Paranoia

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