Below is a table summarizing 29 disorders for which ACMG recommends newborns be screened.
| Type of disorder | Disorder |
| Endocrine disorders | Primary congenital hypothyroidism (CH) |
| Congenital adrenal hyperplasia (CAH) |
| Hemoglobinopathies | Sickle cell anemia (HbSS or HbSߺ Thalassemia) |
| Hemoglobin SC disease (HbSC) |
| Hemoglobin S/beta Thalassemia (HbSß+) |
| Genetic disorders | Biotinidase deficiency |
| Cystic Fibrosis (CF) |
| Hearing Loss |
| Metabolic: Galactosemias | Classical galactosemia |
| Metabolic: Fatty acid oxidation disorders | Medium-chain acyl-CoA dehydrogenase deficiency (MCAD) |
| Very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) |
| Long-chain 3-OH acyl-CoA dehydrogenase deficiency (LCHAD) |
| Trifunctional protein deficiency (TFP) |
| Carnitine uptake deficiency (CUD) |
| Metabolic: Organic acidemias | Isovaleric acidemia (IVA) |
| Glutaric acidemia 1 (GA 1) |
| HMG-CoA lyase deficiency |
| Multiple carboxylase deficiency (MCD) |
| Methylmalonic acidemia due to mutase deficiency (MUT) |
| Methylmalonic acidemia cblA and cblB |
| Methylcrotonyl-CoA carboxylase deficiency (3MCC) |
| Beta-ketothiolase deficiency (BKT) |
| Propionic acidemia (PROP) |
| Metabolic: Amino acid acidemias | Phenylketonuria (PKU) |
| Maple syrup urine disease (MSUD) |
| Homocystinuria |
| Citrullinemia |
| Argininosuccinic acidemia (ASA) |
| Tyrosinemia I |
