A group of single gene disorders including structural hemoglobin variants (e.g., sickle cell hemoglobin) and the thalassemias
Precipitated hemoglobin that can be seen inside red blood cells under the microscope
A fat-soluble form of bilirubin that is formed during the initial chemical breakdown of hemoglobin and, while being transported in the blood, is mostly bound to albumin.
An iron disorder and form of anemia resulting from the inability to incorporate iron into hemoglobin in red blood cells (RBCs); it is characterized by the buildup of iron within developing RBCs resulting in abnormal RBCs called sideroblasts. Since the RBCs cannot develop normally, this condition causes anemia.
Abnormally-shaped red blood cells with one or more semicircular portions removed from the cell margin, appearing as though the cells have had "bite" or "bites." The "bites" result from the removal of hemoglobin with an altered structure (denatured) by special cells (macrophages) in the spleen. G6PD deficiency is a common disorder that leads to the...