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Acetaminophen

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Also known as: Paracetamol; [Often referred to by brand name (see MedlinePlus Drug Information)]
Formal name: Acetaminophen

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

U.S. Food and Drug Administration. Press release: FDA recommends health care professionals discontinue prescribing and dispensing prescription combination drug products with more than 325 mg of acetaminophen to protect consumers. Available online at http://www.fda.gov/Drugs/DrugSafety/ucm381644.htm through http://www.fda.gov. Released January 14, 2014. Accessed Aug 4, 2014.

MedlinePlus. National Institutes of Health. Acetaminophen. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html#brand-names through http://www.nlm.nih.gov. Last reviewed January 1, 2014. Accessed August 3, 2014.

Mayo Clinic. Acetaminophen and children: Why dose matters. Available at http://www.mayoclinic.org/healthy-living/childrens-health/in-depth/acetaminophen/art-20046721 through http://www.mayoclinic.org. Last updated April 13, 2014. Accessed August 4, 2014.

Susan E Farrell and Germaine L Defendi. Acetaminophen Toxicity Workup. Medscape. Available online at http://emedicine.medscape.com/article/820200-workup through http://emedicine.medscape.com. Updated June 24, 2014. Accessed August 4, 2014.

Beauchamp G, et.al. Performance of a Multi-disciplinary Emergency Department Observation Protocol for Acetaminophen Overdose. J Med Toxicol. Sep 2013; 9(3): 235–241. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771000/ through http://www.ncbi.nlm.nih.gov. Accessed September 2014.

(May 7, 2013) Patolia S. Acetaminophen Level. Medscape. Available online at http://emedicine.medscape.com/article/2089664-overview#aw2aab6b2 through http://emedicine.medscape.com. Accessed September 2014.

Sources Used in Previous Reviews

MedlinePlus Medical Encyclopedia. Acetaminophen overdose. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/002598.htm. Accessed August 2010.

MedlinePlus Drug Information. Acetaminopen. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html. Accessed August 2010.

MayoClinic.com. Acetaminophen. Available online at http://www.mayoclinic.com/health/drug-information/DR601885 through http://www.mayoclinic.com. Accessed August 2010.

ARUP Lab Tests. Acetaminophen. Available online at http://www.aruplab.com/guides/ug/tests/0090001.jsp through http://www.aruplab.com. Accessed August 2010.

Dart, R. et. al. (© 2006). Acetaminophen Poisoning: an Evidence-Based Consensus. Guideline for Out-of-Hospital Management. Clinical Toxicology 44:1-18, 2006 [On-line information]. PDF available for download at http://www.aapcc.org/archive/FinalizedPMGdlns/APAP%20-%20final%20guideline%209.9.05.pdf through http://www.aapcc.org.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 1238-1239.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 470-471.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE, eds. St. Louis: Elsevier Saunders; 2006, Pp 1807, 1304-1305.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, P. 316.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds, (2005) Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, P. 1840-1841.

Wu, A. and McKay, C., Editors (© 2003). Recommendations For The Use Of Laboratory Tests To Support Poisoned Patients Who Present To The Emergency Department. The National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines, SECTION IV. Recommendations on Laboratory Assays for Other Toxicants as Causes of Poisonings: A. "Universal" acetaminophen and salicylate screening [On-line information]. Available online at http://www.aacc.org/SiteCollectionDocuments/NACB/LMPG/toxicology/emergency_lmpg.pdf#page=28 through http://www.aacc.org. Accessed August 2010.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 361-364, 684-685.

(Sept 23 2009) Farrell S. Toxicity, Acetaminophen: Treatment and Medication. Medscape article. Available online at http://emedicine.medscape.com/article/820200-treatment through http://emedicine.medscape.com. Accessed August 2010.