1. Can my doctor diagnose tuberculosis without testing my pleural fluid?
The doctor cannot diagnose tuberculosis in the pleural space without testing the pleural fluid. If the infection is present in your lungs, then sputum may be collected, or if meningitis is suspected, CSF would be tested.
2. Should everyone with suspected tuberculosis have an ADA test performed?
The ADA test is primarily performed when tuberculosis is suspected in the pleurae, and it is not routinely available in all laboratories. It will be performed when a doctor determines that it will be useful and timely in helping to diagnose or rule out tuberculosis.
ADA is an enzyme that converts one byproduct into another byproduct. The first substance is toxic to lymphocytes and must be inactivated by ADA. With ADA deficiency, a rare inherited condition, the body makes insufficient ADA. This leads to the buildup of the toxic byproduct and can cause severe combined immunodeficiency disease (SCID). Infants with this condition have seriously compromised immune systems and may not survive without bone marrow transplantation.
This article was last reviewed on May 18, 2012. | This article was last modified on October 8, 2014.
The review date indicates when the article was last reviewed from beginning to end to ensure that it reflects the most current science. A review may not require any modifications to the article, so the two dates may not always agree.
The modified date indicates that one or more changes were made to the article. Such changes may or may not result from a full review of the article, so the two dates may not always agree.