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Alpha-1 Antitrypsin

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Also known as: Alpha1-antitrypsin; A1AT; AAT
Formal name: Alpha1 Antitrypsin; α1-antitrypsin

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

(Updated 2012 September 17). Alpha1-Antitrypsin Deficiency. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/295686-overview through http://emedicine.medscape.com. Accessed May 2013.

Dugdale, D. (Updated 2013 March 22). Alpha-1 antitrypsin test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003715.htm. Accessed May 2013.

Grenache, D. et. al. (Updated 2013 March). Alpha-1-Antitrypsin Deficiency – AAT. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/AAT.html?client_ID=LTD through http://www.arupconsult.com. Accessed May 2013.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 40-41.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 234-235.

(February 2003) American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency. PDF available for download at http://www.thoracic.org/statements/resources/respiratory-disease-adults/alpha1.pdf through http://www.thoracic.org. Accessed May 2013.

(2006) American Thoracic Society. Patient Information series: What is alpha-1-antitrypsin deficiency? PDF available for download at http://patients.thoracic.org/information-series/en/resources/what-is-alpha-1-antitrypsin-deficiency.pdf through http://patients.thoracic.org. Accessed May 2013.

(February 2011) American Lung Association. Chronic Obstructive Pulmonary Disease Factsheet: Alpha1 antitrypsin deficiency-related (AAT) emphysema. Available online at http://www.lung.org/lung-disease/copd/resources/facts-figures/COPD-Fact-Sheet.html through http://www.lung.org. Accessed May 2013.

(January 2013) Genetics Home Reference. Alpha-1 antitrypsin deficiency. Available online at http://ghr.nlm.nih.gov/condition/alpha-1-antitrypsin-deficiency through http://ghr.nlm.nih.gov. Accessed May 2013.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Barclay, L. and Lie, D. (2003 October 10). New Guidelines for Alpha-1 Antitrypsin Deficiency. Medscape Medical News [On-line News and CME]. Available online at http://www.medscape.com/viewarticle/462776 through http://www.medscape.com.

Huskey, R., Maintained (1998 November 10, Updated). Alpha-1 Antitrypsin Deficiency. From Principles of Medical Genetics by Gelehrter and Collins, 1990 (Williams & Wilkins). Available online at http://www.people.virginia.edu/~rjh9u/antitryp.html through http://www.people.virginia.edu.

Maxton, D. (2000 August 21). Alpha-1 antitrypsin deficiency. Netdoctor.co.uk [On-line information]. Available online at http://www.netdoctor.co.uk/diseases/facts/alpha1def.htm through http://www.netdoctor.co.uk.

Shaffer, E. Alpha1-Antitrypsin Deficiency. The Merck Manual – Second Home Edition [On-line information]. Available online at http://www.merck.com/pubs/mmanual_home2/sec10/ch136/ch136f.htm through http://www.merck.com.

Alpha-1 Related Emphysema. American Lung Association [On-line information]. Available online at http://www.lungusa.org/diseases/luna1ad.html through http://www.lungusa.org.

University of Utah (2003). Alpha-1-antitrypsin. Genetic Testing of Newborn Infants, Genetic Science Learning Center [On-line information]. Available online at http://gslc.genetics.utah.edu/units/newborn/infosheets/alpha.cfm through http://gslc.genetics.utah.edu.

Alpha-1 Antitrypsin Deficiency. Children’s Liver Disease Foundation [On-line information]. Available online at http://www.childliverdisease.org/aatd.html through http://www.childliverdisease.org.

Alpha-1 Antitrypsin Deficiency (A-1ATD). MedicineNet.com [On-line information]. Available online at http://www.medicinenet.com/Alpha_1_Antitrypsin_Deficiency/article.htm through http://www.medicinenet.com.

Alpha-1-Antitrypsin and Alpha-1-Antitrypsin Phenotype. ARUP's Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_al38.jsp#1141235 through http://www.aruplab.com.

Kaufman, D. (2003 May 7). Alpha-1 Antitrypsin Deficiency. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000120.htm.

Martell, B. (2003 May 12). Alpha-1 antitrypsin. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003715.htm.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 45-46.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp 198-199.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 138-143.

Fairman P, and Malhotra R. (2008 October 29, Updated). Alpha1-Antitrypsin Deficiency. eMedicine [On-line information]. Available online at http://www.emedicine.com/med/TOPIC108.HTM through http://www.emedicine.com. Accessed March 2009.

Ohar, J. (2008 January 15). New Data on Chronic Obstructive Pulmonary Disease CME/CE. Medscape from CHEST 2007: Pulmonary Disease [On-line information]. Available online at http://www.medscape.com/viewarticle/568542 through http://www.medscape.com. Accessed March 2009.

(2007 November). What Is Alpha-1 Antitrypsin Deficiency? National Heart, Lung, and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/aat/aat_whatis.html through http://www.nhlbi.nih.gov. Accessed March 2009.

(2007 September 28, Updated). Alpha-1 Antitrypsin Deficiency. American Liver Foundation [On-line information]. Available online at http://www.liverfoundation.org/education/info/alphaone/ through http://www.liverfoundation.org. Accessed March 2009.