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Aminoglycoside Antibiotics

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Also known as: [Sometimes referred to by brand name (see MedlinePlus Drug Information)]
Formal name: Gentamicin; Tobramycin; Amikacin

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Article reviewed May 2015 by Jennifer M. Colby, PhD, DABCC.

(March 6, 2014). Drew, R.H. Dosing and administration of parenteral aminoglycosides. UpToDate. Available online at http://www.uptodate.com/contents/dosing-and-administration-of-parenteral-aminoglycosides through http://www.uptodate.com. Accessed on 5/6/15.

(July 16, 2014). Drew, R.H. Aminoglycosides. UpToDate. Available online at http://www.uptodate.com/contents/aminoglycosides through http://www.uptodate.com. Accessed on 5/6/15.

Wong, G. et al. How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients? BMC Infectious Diseases. 2014 14:288.

Banerjee, S., Narayanan, M., and Gould K. Monitoring aminoglycoside level. BMJ. 2012 345:e6354.

Roberts, J.A. et al. Individualized antibiotic dosing for patients who are critically ill: challenges and potential solutions. The Lancet. 2014. 14:498-509.

Clarke, W. Editor. Contemporary Practice in Clinical Chemistry. 2nd Edition, AACC Press, Washington DC.

(©2013) UCSF Infectious Disease Management Program. Guidelines for Antimicrobial Dosing in Adults, Aminoglycosides. Available online at http://idmp.ucsf.edu/aminoglycoside-dosing-and-monitoring-recommendations through http://idmp.ucsf.edu. Accessed May 2015.

Sources Used in Previous Reviews

Billings, K. (Updated 2012 April 6). Ototopical Antibiotics. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/873963-overview through http://emedicine.medscape.com. Accessed September 2012.

Devabhakthuni, S. (Updated 2011 May). Antibiotic Pharmacokinetic Monitoring. American Society of Health-System Pharmacists [On-line information]. Available online at http://www.ashp.org/DocLibrary/MemberCenter/NPF/2011Pearls/Antibiotic-Pharmacokinetic-Monitoring.aspx through http://www.ashp.org. Accessed September 2012.

Dugdale, D. (Updated 2011 September 20). Acute tubular necrosis. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000512.htm. Accessed September 2012.

(© 2012). Causes of Dizziness. Vestibular Disorders Association [On-line information]. Available online at http://vestibular.org/node/2 through http://vestibular.org. Accessed September 2012.

(Reviewed 2010 May). Aminoglycoside Extended Interval Dosing and Monitoring in Adults. New York-Presbyterian Hospital Guideline: Medication Use Manual [On-line information]. Available online through http://www.cumc.columbia.edu. Accessed September 2012.

(© 1984-2012). Section 2 Aminoglycosides. RxKinetics Pharmacokinetic Concepts [On-line information]. Available online at http://www.rxkinetics.com/pktutorial/2_3.html through http://www.rxkinetics.com. Accessed September 2012.

Moulds, R. and Jeyasingham, M. (2010 October). Gentamicin: a great way to start. Aust Prescr v 33 (5) 134–5. [On-line information]. Available online at http://www.australianprescriber.com/magazine/33/5/134/5 through http://www.australianprescriber.com. Accessed September 2012.

(© 2002). Ototoxicity. Vestibular Disorders Association [On-line information]. Available online at http://vestibular.org/ototoxicity through http://vestibular.org. Accessed September 2012.

Mudd, P. (2012 May 7). Ototoxicity. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/857679-overview#showall through http://emedicine.medscape.com. Accessed September 2012.

Lerma, E. et. al. (2011 March 29). Pathophysiologic Mechanisms of Selected Types of Nephrotoxicity. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1925868-overview throughhttp://emedicine.medscape.com. Accessed September 2012.

Gonzalez, U. and Spencer, J. (1998 November 15). Aminoglycosides: A Practical Review. Am Fam Physician. v58 (8):1811-1820. [On-line information]. Available online at http://www.aafp.org/afp/1998/1115/p1811.html throughhttp://www.aafp.org. Accessed September 2012.

Levison, M. (Revised 2009 July). Aminoglycosides. Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed September 2012.

Jasmin, L. (Updated 2011 October 30). Vertigo-associated disorders. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/001432.htm. Accessed September 2012.

Tan, K. et. al. (2003 March 15). Aminoglycoside Prescribing and Surveillance in Cystic Fibrosis. Am. J. Respir. Crit. Care Med v167 (6) 819-823 [On-line information]. Available online at http://ajrccm.atsjournals.org/content/167/6/819.full through http://ajrccm.atsjournals.org. Accessed September 2012.

Levison, M. (Revised 2008 September). Antibiotics. Merck Manual Home Health Handbook [On-line information]. Available online at http://www.merckmanuals.com/home/print/infections/antibiotics/antibiotics.html through http://www.merckmanuals.com. Accessed September 2012.

(2011 April 18). Extended Interval Aminoglycoside Monitoring and Dosing Guideline (Gentamicin/Tobramycin ONLY). Alberta Health Services, Covenant Health, Regional Laboratory Services [On-line information]. Available online through http://www.albertahealthservices.ca. Accessed September 2012.

Hammett-Stabler, C. and Johns, T. (1998 May). Laboratory guidelines for monitoring of antimicrobial drugs. Clinical Chemistry May 1998 v 44 (5) 1129-1140. [On-line information]. Available online at http://www.clinchem.org/content/44/5/1129.full through http://www.clinchem.org. Accessed September 2012.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 581.

(June 18, 2012) UCSF Infectious Disease Management Program, Guidelines for Antimicrobial Dosing in Adults, Aminoglycosides. Available online at http://clinicalpharmacy.ucsf.edu/idmp/adult_guide/aminoglycoside_dosing.htm through http://clinicalpharmacy.ucsf.edu. Accessed October 2012.