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ANCA/MPO/PR3 Antibodies

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Also known as: ANCA Antibodies; cANCA; pANCA; Serine Protease 3; MPO; PR3; Anticytoplasmic Autoantibodies; 3-ANCA; PR3-ANCA; MPO-ANCA
Formal name: Antineutrophil Cytoplasmic Antibodies; Myeloperoxidase Antibodies; Proteinase 3 Antibodies

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

(© 1995–2014). Cytoplasmic Neutrophil Antibodies, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/9441 through http://www.mayomedicallaboratories.com. Accessed April 2014

Schlaberg, R. and Tebo, A. (Reviewed 2014 March). Inflammatory Bowel Disease – IBD. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/IBD.html through http://www.arupconsult.com. Accessed April 2014

Rowe, W. and Lichtenstein, G. (Updated 2013 November 25). Inflammatory Bowel Disease. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/179037-overview through http://emedicine.medscape.com. Accessed April 2014

Ghazi, L. (Updated 2014 January 13). Crohn Disease. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/172940-overview through http://emedicine.medscape.com. Accessed March 2014.

Basson, M. (Updated 2013 May 27). Ulcerative Colitis. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/183084-overview through http://emedicine.medscape.com. Accessed March 2014.

(Reviewed 2012 December). Inflammatory Bowel Disease Differentiation Panel. Quest Diagnostics [On-line information]. Available online at http://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_IBD_Differention_Panel through http://www.questdiagnostics.com. Accessed April 2014

Walfish, A. and Sachar, D. (Revised 2012 December). Crohn Disease. Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed March 2014.

Furata, S. and Jayne, D. (2014). Emerging Therapies in Antineutrophil Cytoplasm Antibody-Associated Vasculitis. Medscape Multispecialty from Curr Opin Rheumatol. 2014;26(1):1-6. [On-line information]. Available online at http://www.medscape.com/viewarticle/821352 through http://www.medscape.com. Accessed April 2014

(2011 April 1). What is Vasculitis? National Heart, Lung, and Blood Institute. [On-line information]. Available online at http://www.nhlbi.nih.gov/health/health-topics/topics/vas/ through http://www.nhlbi.nih.gov. Accessed April 2014

Bronfenbrener, R (October 12, 2012) Antineutrophil Cytoplasmic Autoantibody, Cytoplasmic (c-ANCA). Medscape Reference. Available online at http://emedicine.medscape.com/article/2086572-overview through http://emedicine.medscape.com. Accessed May 2014.

Millet A, et. al. Antineutrophil Cytoplasmic Antibody-Associated Vasculitides. Ann Rheum Dis. 2013;72(8):1273-1279. Available online at http://www.medscape.com/viewarticle/809119 through http://www.medscape.com. Accessed May 2014.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 90-91.

Shah A, Bylund DJ, McCallum RM. (2011) Vasculitis, in Henry's Clinical Diagnosis by Laboratory Methods, 22nd ed. McPherson RA, Pincus MR, eds. Elsevier-Saunders: Philadelphia.Chap 52, Pp 991-1002.

Watnick S, Dirkx T (2014). Kidney Disease, in Current Medical Diagnosis and Treatment. Papadakis MA, McPhee SJ, Rabow MW., eds. McGraw-Hill:New York. Chap 22.

Nachman PH, Denu-Ciocca CJ. (2009). Chapter 31. Vasculitides. In: Lerma EV, Berns JS, Nissenson AR. eds. CURRENT Diagnosis & Treatment: Nephrology & Hypertension. New York, NY: McGraw-Hill.

Sources Used in Previous Reviews

(2009 March). Vasculitis. National Heart Lung and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/vas/vas_whatis.html through http://www.nhlbi.nih.gov. Accessed June 2010.

(© 2006-2010). MPO/PR-3 (ANCA) Antibodies : 0050707. ARUP's Laboratory Test Directory [On-line information]. Available online at http://www.aruplab.com/guides/ug/tests/0050707.jsp through http://www.aruplab.com. Accessed June 2010.

(Updated 2009 August). Vasculitis – ANCA. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/ANCA.html?client_ID=LTD through http://www.arupconsult.com. Accessed June 2010.

Borigini, M.J. (Updated 2009 May 31). Necrotizing Vasculitis. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000432.htm. Accessed June 2010.

Mayo Clinic Staff (2009 October 10). Vasculitis [On-line information]. Available online at http://www.mayoclinic.com/health/vasculitis/DS00513/METHOD=print through http://www.mayoclinic.com. Accessed June 2010.

Revelo, P. and Tebo, A. (Updated 2009 August). Goodpasture Syndrome - Anti-GBM Disease. (ARUP Consult) [On-line information]. Available online at http://www.arupconsult.com/Topics/GoodpastureSyndrome.html?client_ID=LTD# through http://www.arupconsult.com. Accessed June 2010.

Gota, C. (Updated 2008 May). Introduction: Vasculitis. Merck Manual for Healthcare Professionals [On-line information]. Available online at http://www.merck.com/mmpe/sec04/ch033/ch033a.html through http://www.merck.com. Accessed June 2010.

Trevisin, M. et. al. (2008 March 10). Antigen-Specific ANCA ELISAs Have Different Sensitivities for Active and Treated Vasculitis and for Nonvasculitic Disease. Medscape from American Journal of Clinical Pathology. 2008;129(1):42-53 [On-line information]. Available online at http://www.medscape.com/viewarticle/568996 through http://www.medscape.com. Accessed June 2010.

(Updated 2009 January 30). Anti-Neutrophile Cytoplasmic Antibody, Serum. Pathology Associates of Lexington, P.A. [On-line information]. Available online at http://www.palpath.com/MedicalTestPages/anca.htm through http://www.palpath.com. Accessed June 2010.

(© 1995–2010) Unit Code 83012: Antineutrophil Cytoplasmic Antibodies Vasculitis Panel, Serum. Mayo Clinic, Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/83012 through http://www.mayomedicallaboratories.com. Accessed June 2010.

Papadopoulos, P. and O’Brian, R. (Updated 2009 August 4). Wegener Granulomatosis. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/332622-overview through http://emedicine.medscape.com. Accessed June 2010.

Lohr, J. and Owens, K. (Updated 2008 September 4). Glomerulonephritis, Rapidly Progressive. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/240457-overview through http://emedicine.medscape.com. Accessed June 2010.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 88-89.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO., Pp 750-751, 928-929.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 935-937.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds (2005). Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 2002-2003.