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Anti-LKM-1

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Also known as: Liver Kidney Microsomal Type 1 Antibodies; LKM1 Antibodies; Anti-Liver/Kidney Microsomal Antibodies Type 1; Anti-LKM1; Anti-P450 2D6 Antibody
Formal name: Liver Kidney Microsome Type 1 Antibodies (Cytochrome P450 2D6 Antibodies)

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2017 review performed by Rose Romeo, PhD, DABCC, FACB.

Bogdanos, DP, Invernizzi, P, Mackay, IR and D vergani (2008). Autoimmune liver serology: Current diagnostic and clinical challenges. World Journal of Gastroenterology, vol 14: 3374-3387.

European Association for the Study of the Liver (EASL) Clinical Practice Guidelines: Autoimmune hepatitis (2015). Journal of Hepatology, vol 63: 971-1004.

Czaja, AJ (2016). Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions. Gut and Liver, vol 10: 177-203.

Narciso-Schiavon, JL and LL Schiavon (2017). To screen or not to screen? Celiac antibodies in liver diseases. World Journal of Gastroenterology, vol. 23: 776-791.

Himoto, T & M Nishioka (2013) Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis. Autoimmune Highlights. Vol 4: 39-53.

Wolf, D (2016). Medscape Article: Autoimmune hepatitis. Available online at emedicine.medscape.com/article/172356-overview. Accessed April 28th, 2017.

ARUP. Liver-Kidney Microsome Antibody, IgG (2017). Available online at ltd.aruplab.com/Tests/Pub/0099270. Accessed on April 29th 2017.

Sources Used in Previous Reviews

(Updated 2012 February 16). Autoimmune Hepatitis. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [On-line information]. Available online at http://digestive.niddk.nih.gov/ddiseases/pubs/autoimmunehep/. Accessed August 2013.

Longstreth, G. (Updated 2012 October 8) Autoimmune hepatitis. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000245.htm. Accessed August 2013.

Slev, P. and Tebo, A. (Updated 2013 February). Hepatitis, Autoimmune – AIH. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/AIH.html?client_ID=LTD. Accessed August 2013.

((©) 1995 – 2013). Liver/Kidney Microsome Type 1 Antibodies, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/80387. Accessed August 2013

Wolf, D. and Raghuraman, U. (Updated 2013 July 29). Autoimmune Hepatitis. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/172356-overview. Accessed August 2013.

Shaffer, E. (Revised 2009 June). Laboratory Tests of the Liver and Gallbladder. Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed August 2013.

Mayo Clinic Staff (2012 April 18). Autoimmune hepatitis. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/autoimmune-hepatitis/DS00676. Accessed August 2013.

Mieli-Vergani, G. (2009 August). Autoimmune Hepatitis. J Pediatr Gastroenterol Nutr, v 49 (2) [On-line information]. Available online at http://journals.lww.com/jpgn/Fulltext/2009/08000/Autoimmune_Hepatitis.2.aspx. Accessed August 2013.

Trivedi, P. and Hirschfield, G. (2012). Review Article: Overlap Syndromes and Autoimmune Liver Disease. Medscape Today News from Aliment Pharmacol Ther. 2012;36(6):517-533. [On-line information]. Available online at http://www.medscape.com/viewarticle/770010_1. Accessed August 2013.

Stephen Kriese, S. and Heneghan, M. (2013). Current Concepts in the Diagnosis and Management of Autoimmune Hepatitis. Medscape Multispecialty from Frontline Gastroenterol. 2013;4(1):2-11. http://www.medscape.com/viewarticle/776365. Accessed September 2013.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 314.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 682-683.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, pg 951.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE, eds. 4th edition, St. Louis: Elsevier Saunders; 2006, pp 1812-1814.