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PTT

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Also known as: Activated Partial Thromboplastin Time; aPTT; APTT
Formal name: Partial Thromboplastin Time

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Dugdale, D.C. (Updated 2011 February 13) Partial Thromboplastin Time (PTT). National Institutes of Health Medline Plus. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm through http://www.nlm.nih.gov/. Accessed May 2014.

Hammami, M. B. (Updated 2013 February 20). Partial Thromboplastin Time, Activated. Medscape. Available online at http://emedicine.medscape.com/article/2085837-overview through http://emedicine.medscape.com. Accessed May 2014.

(© 1995–2014). Activated Partial Thromboplastin Time (APTT), Plasma. Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9058 through http://www.mayomedicallaboratories.com. Accessed May 2014.

Tuazon, S.A. et al. (Updated 2012 September 4). Prothrombin Time. Available online at http://emedicine.medscape.com/article/2086058-overview through http://emedicine.medscape.com. Accessed May 2014.

Pollak, E.S. (Updated 2012 April 6). von Willebrand Disease. Medscape. Available online at http://emedicine.medscape.com/article/206996-overview through http://emedicine.medscape.com. Accessed May 2014.

Pagana, K. D. & Pagana, T. J. (© 2014). Mosby's Manual of Diagnostic and Laboratory Tests Reference 5th Edition: Mosby, Inc., Saint Louis, MO. Pp 383-386.

(Reviewed 2013 February). Recurrent Miscarriage Evaluation/Coagulation Panel. Quest Diagnostics. Available online at http://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_Recurrent_Miscarriage through http://www.questdiagnostics.com. Accessed May 2014.

Moake, J. (Reviewed 2012 July). Excessive Bleeding. The Merck Manual. Available online at http://www.merckmanuals.com/professional/hematology_and_oncology/hemostasis/excessive_bleeding.html?qt=partial%20thromboplastin&alt=sh through http://www.merckmanuals.com. Accessed May 2014.

Moake, J. (Reviewed 2013 December). Coagulation Disorders Caused by Circulating Anticoagulants. The Merck Manual. Available online through http://www.merckmanuals.com. Accessed May 2014.

Eke, Sancar. (Reviewed 2012 March). Medscape. Heparin-Induced Thrombocytopenia Treatment & Management. Available online at http://emedicine.medscape.com/article/1357846-treatment through http://emedicine.medscape.com. Accessed May 2014.

Szigeti, Reka. (Updated 2012 October). Anti-Xa Assay (Heparin Assay). Medscape. Available online at http://emedicine.medscape.com/article/2085000-overview#a30 through http://emedicine.medscape.com. Accessed May 2014.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

(2002 November 19, Modified). Activated Partial Thromboplastin Time. Mass Gen. Hospital Pathology Service Laboratory Medicine [On-line information, Coag Test Handbook]. Available online at http://www.mgh.harvard.edu/labmed/lab/coag/handbook/co003400.htm#co003400 through http://www.mgh.harvard.edu.

Activated Partial Thromboplastin Time. MCL Web Resources, Topics in Hemostasis [On-line information]. Available online at http://155.58.145.40/hemostasis/PTT1.html.

Olson, J. (1999 September). Addressing clinical etiologies of a prolonged aPTT. CAP Today, In the News [On-line Newsletter]. Available online at http://www.cap.org/captoday/CaseStudy/coag4.html through http://www.cap.org.

Activated Partial Thromboplastin Time. Florida Hospital Cancer Institute, Clinical and Research Laboratories Coagulation Test Panels [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm through http://www.fhci-labs.com.

PTT-LA. Florida Hospital Cancer Institute, Clinical and Research Laboratories Coagulation Test Panels [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm through http://www.fhci-labs.com/.

Duke University Medical Center Clinical Coagulation Laboratory Coagulation Test Descriptions [On-line information]. Available online at http://pathology.mc.duke.edu/coag/TestDes.htm through http://pathology.mc.duke.edu.

Elstrom, R. (2001 November 25, Updated ). PTT. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm.

Coagulation Test Panels. Clinical and Research Laboratories, Florida Hospital Cancer Institute [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm through http://www.fhci-labs.com.

Menta, S. (1999 Spring). The Coagulation Cascade. Physiology Disorders Evaluation, College of Medicine, Univ of Florida [On-line information]. Available online at http://www.medinfo.ufl.edu/year2/coag/title.html through http://www.medinfo.ufl.edu.

Elstrom, R. (2001 November 25, Updated). PT. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm.

Elstrom, R. (2001 November 25, Updated). PTT. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm.

What is a Bleeding Disorder? National Hemophilia Foundation, Bleeding Disorders Info Center [On-line information]. Available online at http://www.hemophilia.org/bdi/bdi_general.htm through http://www.hemophilia.org.

DeLoughery, T. (1999 March 15). Tests of Hemostasis and Thrombosis. OHSU [Online student handout]. Available online at http://www.ohsu.edu/som-hemonc/handouts/deloughery/printtest.html through http://www.ohsu.edu.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 705-707.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Harris, N. et. al. Chapter 19: Assessment of Hemostasis in the Clinical Laboratory. Pp 227-239.

Dugdale, D. (Updated 2010 August 19). Partial thromboplastin time (PTT). MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm. Accessed September 2010.

(© 1995–2010). Unit Code 9058: Activated Partial Thromboplastin Time (APTT), Plasma. Mayo Clinic, Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/9058 through http://www.mayomedicallaboratories.com. Accessed September 2010.

Ballas, M. and Kraut, E. (2008 April 15). Bleeding and Bruising: A Diagnostic Work-up. Am Fam Physician. 2008 Apr 15;77(8):1117-1124. [On-line information]. Available online at http://www.aafp.org/afp/2008/0415/p1117.html through http://www.aafp.org. Accessed September 2010.

(© 1996 – 2010). 3895: Activated Partial Thromboplastin Time (APTT). Specialty Laboratories [On-line information]. Available online at http://www.specialtylabs.com/tests/details.asp?id=3895 through http://www.specialtylabs.com. September June 2010.

(© 1995-2010). Blood Test: Partial Thromboplastin Time (PTT). KidsHealth from Nemours [On-line information]. Available online at http://kidshealth.org/parent/system/medical/test_ptt.html through http://kidshealth.org. Accessed September 2010.

Moake, J. (Revised 2009 June). Uncommon Hereditary Coagulation Disorders. Merck Manual for Healthcare Professionals [On-line information]. Available online at http://www.merck.com/mmpe/sec11/ch136/ch136e.html through http://www.merck.com. Accessed September 2010.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 705-707.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 46-47, 932-933.

(January 2008) How to Interpret and Pursue an Abnormal Prothrombin Time, Activated Partial Thromboplastin Time and Bleeding Time. MyoMedialLaboratories.com, Vol. 33 No.1. PDF available for download at http://www.mayomedicallaboratories.com/mediax/articles/communique/2008/mc2831-0108.pdf through http://www.mayomedicallaboratories.com. Accessed September 2010.

Jacobs DS, DeMott WR, Oxley DK. Laboratory Test Handbook, 5th ed.Lexicomp: Hudson, OH. Coagulation: EM Van Cott & M Laposata, Pp 327-358, 2001.

Florida Hospital, Center for Thrombosis Research, © 2008, PTT-LA. Available online at http://www.fhthrombosis.com/PTT-LA through http://www.fhthrombosis.com. Accessed October 2010.