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BCR-ABL1

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Also known as: BCR/ABL; bcr-abl Oncogene; Philadelphia Chromosome
Formal name: BCR-ABL1 Fusion

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Gregory J. Tsongalis, PhD, HCLD, CC. Professor of Pathology, Director, Molecular Pathology, Dartmouth Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, NH.

BCR/ABL, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Qualitative, Diagnostic Assay. Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83336 through http://www.mayomedicallaboratories.com. Accessed February 2014.

BCR/ABL, p210, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Chronic Myelogenous Leukemia (CML). Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89007 through http://www.mayomedicallaboratories.com. Accessed February 2014.

(Revised December 30 2013). How is Chronic Myeloid Leukemia Diagnosed? American Cancer Society. Available online at http://www.cancer.org/cancer/leukemia-chronicmyeloidcml/detailedguide/leukemia-chronic-myeloid-myelogenous-diagnosis through http://www.cancer.org. Accessed February 2014.

(Revised December 2013). Targeted Therapies for Chronic Myeloid Leukemia. American Cancer Society. Available online at http://www.cancer.org/cancer/leukemia-acutelymphocyticallinadults/detailedguide/leukemia-acute-lymphocytic-treating-targeted-therapy through http://www.cancer.org. Accessed February 2014.

(Updated: Jan 6, 2014) Besa E. Chronic Myelogenous Leukemia. Medscape Reference. Available online at http://emedicine.medscape.com/article/199425-overview#aw2aab6b2b2 through http://emedicine.medscape.com. February 2014.

(Revised 2013 July 10). What's New in Acute Lymphomatic Leukemia Research and Treatment? American Cancer Society. Available online at http://www.cancer.org/cancer/leukemia-acutelymphocyticallinadults/detailedguide/leukemia-acute-lymphocytic-new-research through http://www.cancer.org. Accessed February 2014.

Seiter, K. et al. (Updated 2014 Jan. 2). Acute Lymphoblastic Leukemia. eMedicine. Available online at http://emedicine.medscape.com/article/207631-overview through http://emedicine.medscape.com. Accessed February 2014.

Bessa, Emmanuel C. (Updated 6 January 2013). Chronic Myelogenous Leukemia. Medscape. Available online at http://emedicine.medscape.com/article/199425-overview through http://emedicine.medscape.com. Accessed February 2014.

(December 2013). BCR-ABL1 Quantitative Testing. Arup Laboratories. Available online at http://ltd.aruplab.com/Tests/Pdf/143 through http://ltd.aruplab.com. Accessed February 2014.

Sources Used in Previous Reviews

Besa, E. and Woermann, U. (Updated 2010 March 16). Chronic Myelogenous Leukemia. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/199425-overview through http://emedicine.medscape.com. Accessed September 2010.

Markman, M. (Updated 2009 August 26). Chronic Myeloid Leukemia and BCR-ABL. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/1723784-overview through http://emedicine.medscape.com. Accessed September 2010.

Leukemia - Chronic Myeloid (CML) Detailed Guide. American Cancer Society [On-line information]. Available online at http://www.cancer.org/Cancer/Leukemia-ChronicMyeloidCML/DetailedGuide/index through http://www.cancer.org. Accessed September 2010.

(Reviewed 2010 June 21). Targeted Cancer Therapies. National Cancer Institute Fact Sheet [On-line information]. Available online at http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted through http://www.cancer.org. Accessed September 2010.

Mayo Clinic Staff (2008 November 13). Chronic myelogenous leukemia. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/chronic-myelogenous-leukemia/DS00564 through http://www.mayoclinic.com. Accessed September 2010.

Mayfield, E. (2009 October 20). Better Options for Children with Difficult-to-Treat Leukemia. NCI Cancer Bulletin v6 (20) [On-line information]. Available online at http://www.cancer.gov/ncicancerbulletin/102009/page2 through http://www.cancer.gov. Accessed September 2010.

Hazlehurst, L. et. al. (2009 August 25). Signaling Networks Associated with BCR-ABL–Dependent Transformation. Medscape from Cancer Control. 2009;16(2):100-107 [On-line information]. Available online at http://www.medscape.com/viewarticle/705840 through http://www.medscape.com. Accessed September 2010.

Chabner, B. and Chabner Thompson, E. (Revised 2009 July). Modalities of Cancer Therapy. Merck Manual for Healthcare Professionals [On-line information]. Available online at http://www.merck.com/mmpe/sec11/ch149/ch149b.html?qt=bcr-abl&alt=sh through http://www.merck.com. Accessed September 2010.

Ho, A. et. al. (Updated 2010 January). Chronic Myelogenous Leukemia – CML. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/CML.html?client_ID=LTD through http://www.arupconsult.com. Accessed September 2010.

Padmanabhan, S. et. al. (2008 July 15). Current Status of Therapy for Chronic Myeloid Leukemia: A Review of Drug Development. Medscape from Future Oncology 2008;4(3):359-377 [On-line information]. Available online at http://www.medscape.com/viewarticle/576209 through http://www.medscape.com. Accessed September 2010.

Mahadevan, D. (Updated 2010 January 3). Targeted Cancer Therapy. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/1372666-overview through http://emedicine.medscape.com. Accessed September 2010.

Esparza, S. et. al. (Updated 2009 February 27). Childhood Cancer, Genetics. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/989983-overview through http://emedicine.medscape.com. Accessed September 2010.

Merker, J. (2009 January 30). Use of Quantitative PCR in the Monitoring of Patients with Chronic Myelogenous Leukemia. CAP NewsPath [On-line information]. Available online through http://www.cap.org. Accessed September 2010.

Wang, J. (© 1996-2010). Chronic Myelogenous Leukemia: BCR/ABL. Specialty Laboratories [On-line information]. Available online at http://www.specialtylabs.com/books/display.asp?id=612 through http://www.specialtylabs.com/books. Accessed September 2010.

(© 1995-2010). Unit Code 83336: BCR/ABL, p190, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Assay. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/print.php?unit_code=83336 through http://www.mayomedicallaboratories.com. Accessed September 2010.

(© 1995-2010). Unit Code 89609: BCR/ABL, Tyrosine Kinase Inhibitor Resistance, Kinase Domain Mutation Screen. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/print.php?unit_code=89609 through http://www.mayomedicallaboratories.com. Accessed September 2010.