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Beta-2 Glycoprotein 1 Antibodies

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Also known as: Anti-Beta-2 Glycoprotein 1; β2-Glycoprotein 1 Antibodies; Beta 2GP1 Ab
Formal name: Beta-2 Glycoprotein 1 Antibodies IgG, IgM, and IgA
Related tests: Cardiolipin Antibodies, Lupus Anticoagulant, Antiphospholipid Antibodies, Anti-phosphatidylserine Antibodies, Anti-prothrombin Antibodies

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The Test Sample

What is being tested?

Beta-2 glycoprotein 1 antibody is an autoantibody that is associated with inappropriate blood clotting. This test detects and measures one or more classes (IgG, IgM, or IgA) of beta-2 glycoprotein 1 antibodies.

Beta-2 glycoprotein antibody is considered one of the primary autoantibodies called antiphospholipid antibodies that mistakenly target the body's own lipid-proteins (phospholipids) found in the outermost layer of cells (cell membranes) and platelets. This test is often ordered along with those for the other antiphospholipid antibodies, cardiolipin antibody and lupus anticoagulant.

Antiphospholipid antibodies interfere with the body's blood clotting process in a way that is not fully understood. Their presence increases a person's risk of developing inappropriate blood clots (thrombi) in both arteries and veins. Antiphospholipid antibodies are most frequently seen in people with the autoimmune disorder called antiphospholipid syndrome (APS), which is associated with blood clots (thrombotic episodes), a low platelet count (thrombocytopenia), or with pregnancy complications such as pre-eclampsia and recurrent miscarriages, especially in the second and third trimesters.

One or more antiphospholipid antibodies may also be seen with other autoimmune disorders, such as lupus (systemic lupus erythematosus, SLE).

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in the arm.

NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.

Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is needed.