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Beta-2 Microglobulin Tumor Marker

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Also known as: B2M; B2M; β2-Microglobulin; Thymotaxin
Formal name: Beta2 Microglobulin, Serum, Urine, or CSF

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2017 review performed by Allison B. Chambliss, PhD, DABCC, FACB, Scientific Director, LAC+USC Medical Center Core Laboratory.

(November 4, 2015) Tumor Markers. NIH National Cancer Institute. Available online at https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet. Accessed on 4/10/17.

(January 19, 2016) How Is Multiple Myeloma Staged? American Cancer Society. Available online at https://www.cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/staging.html. Accessed on 4/10/17.

Palumbo et al. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. Journal of Clinical Oncology 33, no. 26 (September 2015) 2863-2869. Available online at http://ascopubs.org/doi/full/10.1200/jco.2015.61.2267. Accessed on 4/10/17.

Jadeja N, Nalleballe K, Graber, J. Pearls & Oy-sters: Plasma cell meningitis: An uncommon complication of multiple myeloma. Neurology 87, no. 20 (November 2016) e240-e242. Available online at https://www.ncbi.nlm.nih.gov/pubmed/27906664. Accessed on 4/10/17.

Teitz Clinical Guide to Laboratory Tests. Wu AHB, ed. 4th Edition: St. Louis: Elsevier Saunders.

Sources Used in Previous Reviews

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 155-156.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 742-743.

(© 2008). Multiple Myeloma Disease Overview. Multiple Myeloma Research Foundation [On-line information]. PDF available for download at http://www.multiplemyeloma.org/downloads/about_myeloma/MMRF_Disease_Overview.pdf. Accessed August 2009.

(Modified 2009 July 23). General Information About Multiple Myeloma and Other Plasma Cell Neoplasms. National Cancer Institute. [On-line information]. Available online at http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/patient/. Accessed August 2009.

(© 1995–2009). Overview: Beta-2 Microglobulin (B[2]-M), Urine. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/300243. Accessed August 2009.

(© 1995–2009). Overview: Beta-2-Microglobulin (Beta-2-M), Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/9234. Accessed August 2009.

Seiter, K. and Shah, D. (Updated 2013 May 29). Multiple Myeloma. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/204369-overview. Accessed June 2013.

(Modified 2013 May 17). Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®). National Cancer Institute [On-line information]. Available online at http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/patient/. Accessed June 2013.

Mayo Clinic staff (2011 August 16). Multiple myeloma. Mayo Clinic [On-line information]. Available online at http://www.mayoclinic.com/print/multiple-myeloma/DS00415/DSECTION=all&METHOD=print. Accessed June 2013.

(Revised 2013 February 12). Multiple Myeloma. American Cancer Society [On-line information]. Available online at http://www.cancer.org/cancer/multiplemyeloma/detailedguide/index. Accessed June 2013.

Durie, B. (2013). Patient Handbook: Multiple Myeloma. International Myeloma Foundation [On-line information]. Available online at http://myeloma.org/pdfs/Patient_Handbook_2013.pdf. Accessed June 2013.

(Revised 2012). Understanding Lab and Imaging Tests. Leukemia & Lymphoma Society [On-line information]. Available online through http://www.lls.org. Accessed June 2013.

(2011 December 7). Tumor Markers. National Cancer Institute [On-line information]. Available online at http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers. Accessed June 2013.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 680-682.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE, eds. 4th edition, St. Louis: Elsevier Saunders; 2006, Pg 555.