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Blood Ketones

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Also known as: Serum Ketones; Plasma Ketones; Beta-hydroxybutyrate; Ketone Bodies; Beta-hydroxybutyric Acid; Acetoacetate; Acetoacetic Acid; Acetone
Formal name: Blood Ketones
Related tests: Urine Ketones (see Urinalysis - The Chemical Exam); Blood Gases; Glucose Tests

Board approvedAll content on Lab Tests Online has been reviewed and approved by our Editorial Review Board.

Were you looking for urine ketones? Urine ketone testing is more common than blood ketone testing and may be performed as part of a urinalysis.

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2016 review performed by Hui Li, PhD, DABCC, FACB, FCACB, Clinical Chemist, Dynacare.

(Aug. 21, 2015) Mayo Clinic Staff. Diabetic ketoacidosis. Mayoclinic.org [On-line information]. Available online at http://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/basics/definition/con-20026470. Accessed June 2016.

(May 2011) Sacks D. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Clin Chem. Available online at http://www.ncbi.nlm.nih.gov/pubmed/21617152. Accessed June 2016.

(Apr 2011) Stojanovic V. Role of beta-hydroxybutyric acid in diabetic ketoacidosis: A review. Can Vet J. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058661/. Accessed June 2016

(Dec, 1999) Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev. Available online at http://www.ncbi.nlm.nih.gov/pubmed/10634967. Accessed June 2016.

Sources Used in Previous Reviews

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 972-973.

Hurd, R. (Updated 2007 October 31). Serum ketones. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003498.htm. Accessed February 2009.

Holt, E. (Updated 2008 June 17). Diabetic Ketoacidosis MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000320.htm. Accessed February 2009.

Mayo Clinic Staff (2008 February 9). Diabetic ketoacidosis. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/print/diabetic-ketoacidosis/DS00674/DSECTION=all&METHOD=print. Accessed February 2009.

Hamdy, O. (Updated 2008 July 14). Diabetic Ketoacidosis eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/118361-overview. Accessed February 2009.

Trachtenbarg, D. (2005 May 1). Diabetic Ketoacidosis. American Family Physician [On-line information]. Available online at http://www.aafp.org/afp/20050501/1705.html. Accessed February 2009.

Sheikh-Ali, M. et. al. (2008 January). Can Serum _-Hydroxybutyrate Be Used to Diagnose Diabetic Ketoacidosis? Diabetes Care 31:643-647, 2008 [On-line information]. Available online at http://care.diabetesjournals.org/cgi/content/full/31/4/643. Accessed February 2009.

Rose, K. and Collins, K. (2008 December 1). Vitreous Postmortem Chemical Analysis. CAP NewsPath [On-line information]. Available online through http://www.cap.org. Accessed February 2009.

(Updated 2008 December 30). Siezures and Epilepsy, Hope Through Research. NINDS [On-line information]. Available online at http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm. Accessed February 2009.

Rho, J. (Updated 2009 February 19). The Ketogenic Diet in Pediatric Epilepsy. The Charlie Foundation [On-line information]. Available online at http://www.charliefoundation.org/frames/diet/overview.php. Accessed February 2009.

(2006 July). Answering your questions, Serum acetone testing. [On-line information]. PDF available for download at http://www.mlo-online.com/articles/0706/0706tips%20.pdf. Accessed February 2009.

(Modified 2008 August 11). Ketone Testing. Children’s Physician Network [On-line information]. Available online at http://www.cpnonline.org/CRS/CRS/pa_ketone_pep.htm. Accessed February 2009.

Wallace, T. and Matthews, D. (2004). Recent advances in the monitoring and management of diabetic ketoacidosis. QJM 2004 97(12):773-780. Available online at http://qjmed.oxfordjournals.org/cgi/content/full/97/12/773. Accessed February 2009.

Vorvick, L. (Updated 2011 February 1). Serum ketones test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003498.htm. Accessed December 2012.

Devkota, B. (Updated 2012 October 11). Ketone (Acetone). Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/2087982-overview. Accessed December 2012.

Raghavan, V. et. al. (Updated 2012 January 3). Diabetic Ketoacidosis. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/118361-overview. Accessed December 2012.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 404.

McPherson, R. and Pincus, M. (© 2011). Henry's Clinical Diagnosis and Management by Laboratory Methods 22nd Edition: Elsevier Saunders, Philadelphia, PA. Pg 218.