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C-peptide

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Also known as: Insulin C-peptide; Connecting Peptide Insulin; Proinsulin C-peptide
Formal name: C-peptide
Related tests: Insulin; Glucose

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Topiwala, S. (Updated 2012 June 4). Insulin C-peptide. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003701.htm through http://www.nlm.nih.gov. Accessed December 2013.

Elhomsy, G. (Updated 2012 September 7). C-Peptide. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/2087824-overview#showall through http://emedicine.medscape.com. Accessed December 2013.

(© 1995–2013). C-Peptide, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/8804 through http://www.mayomedicallaboratories.com. Accessed December 2013.

Parkin, C. (2013 February). LADA, the Other Diabetes, Can Be Hard to Spot. Diabetes Forecast [On-line information]. Available online at http://www.diabetesforecast.org/2013/feb/lada-the-other-diabetes-can-be-hard-to-spot.html through http://www.diabetesforecast.org. Accessed December 2013.

Weisenberger, J. (2013 March) Why Does a C-Peptide Test Matter? Diabetes Forecast [On-line information]. Available online at http://www.diabetesforecast.org/2013/mar/why-does-a-c-peptide-test-matter.html through http://www.diabetesforecast.org. Accessed December 2013.

Delgado, J. et. al. (Updated 2013 January). Hyperinsulinemic Hypoglycemia. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/HyperinsulinemicHypoglycemia.html?client_ID=LTD#tabs=0 through http://www.arupconsult.com. Accessed December 2013.

Son, S. (2012 October). C-Peptide and Vascular Complications in Type 2 Diabetic Subjects. Diabetes Metab J. v36 (5): 345–349. [On-line information]. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486980/#B13 through http://www.ncbi.nlm.nih.gov. Accessed December 2013.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 317-318.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE, eds. 4th edition, St. Louis: Elsevier Saunders; 2006, Pp 850-851.

Sources Used in Previous Reviews

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Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Torres, A. (2002 August 19, Updated). What is c-peptide? What do c-peptide levels mean? Misc.health.diabetes, diabetes FAQ [On-line information from newsgroup]. Available online at http://www.faqs.org/faqs/diabetes/faq/part1/section-10.html through http://www.faqs.org/faqs/diabetes/faq/part1/section-10.html.

Fish, S., Updated (2002 February 18, Updated). Insulin C-peptide. MEDLINEplus Health Information [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003701.htm.

Tunis, S., et. al. (2001 May 14). Insulin Pump: C-Peptide levels as a Criterion for Use. Center for Medicare & Medicaid Services, Medicare Coverage Policy, NCDs [On-line Decision Memorandum]. Available online at http://cms.hhs.gov/coverage/8b3-ss2.asp through http://cms.hhs.gov.

Liposcience. C-Peptide. Liposcience, Clinicians Testing Menu [On-line information]. Available online at http://www.liposcience.com/clin_tm_cp.htm through http://www.liposcience.com.

CSU (1999 June 15, Updated). Insulin Synthesis and Secretion. Colorado State University, Pathophysiology of the Endocrine System [On-line Biomedical Hypertextbook]. Available online at http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/pancreas/insulin.html through http://arbl.cvmbs.colostate.edu.

WSU (2001 Winter). Researchers gather for symposium on promising treatment for Type 1 diabetes. Wayne State University, Scribe [On-line Newsletter]. Available online at http://www.med.wayne.edu/Scribe/scribe00-01/scribew01/diabetes.htm through http://www.med.wayne.edu.

Warner, J. (2002 April 10). Extra Pounds Raise Breast Cancer Risk. WebMD [On-line Article]. Available online at http://my.webmd.com/condition_center_content/brc/article/1689.52069 through http://my.webmd.com.

Bell, D. (2001 December 1). Editorials, Combination Therapy for Type 2 Diabetes. AAFP, American Family Physician [On-line Journal]. Available online at http://www.aafp.org/afp/20011201/editorials.html through http://www.aafp.org.

ARUP. C-Peptide, Serum. ARUP's Guide to Clinical Laboratory Testing (CLT) [On-line Test Menu]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a110.htm#1058945 through http://www.aruplab.com.

DPC. Clinical Applications of Insulin and C-Peptide Determinations. Diagnostic Products Corporation [On-line testing information]. Available online at http://www.dpcweb.com/medical/diabetes/diabetes_applications_insulin.html through http://www.dpcweb.com.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. St. Louis, Missouri Elsevier Saunders; 2006.

David B. Sacks, David E. Bruns, David E. Goldstein, Noel K. Maclaren, Jay M. McDonald, and Marian Parrott. GUIDELINES AND RECOMMENDATIONS FOR LABORATORY ANALYSIS IN THE DIAGNOSIS AND MANAGEMENT OF DIABETES MELLITUS (Online information, accessed November 2006). Available online through http://www.aacc.org.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pages 186-188.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 314-315.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 290-291.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 186-189.

Holt, E. (Updated 2008 June 17). Insulin C-peptide. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003701.htm. Accessed December 2009.

Dowshen, S. (Reviewed 2009 January) Blood Test: C-Peptide [On-line information]. Available online at http://kidshealth.org/parent/system/medical/test_cpeptide.html through http://kidshealth.org. Accessed December 2009.

(© 1995-2009). Unit Code 8804: C-Peptide, Serum. Mayo Clinic, Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/print.php?unit_code=8804 through http://www.mayomedicallaboratories.com. Accessed December 2009.

Hussain, A. N. and Vincent, M. (Updated 2009 July 2). Diabetes Mellitus, Type 1. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/117739-overview through http://emedicine.medscape.com. Accessed December 2009.

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(Updated 2009 November). Diabetes Mellitus. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/DiabetesMellitus.html?client_ID=LTD# through http://www.arupconsult.com. Accessed December 2009.

Little, R. et. al. (2008 April 17). Standardization of C-Peptide Measurements. Clinical Chemistry. 2008;54:1023-1026. [On-line information]. Available online at http://www.clinchem.org/cgi/content/full/54/6/1023 through http://www.clinchem.org. Accessed December 2009.

(Updated 2009 August). Insulinoma. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Insulinoma.html# through http://www.arupconsult.com. Accessed December 2009.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 186-187.