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CA-125

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Also known as: CA 125 Tumor Marker
Formal name: Cancer Antigen 125

Board approvedAll content on Lab Tests Online has been reviewed and approved by our Editorial Review Board.

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2016 review by Carolyn Sue Ziegler, MBA, MLS(CM).

Pagana, Kathleen D, Pagana, Timothy J, and Pagana, Theresa N. (©2015) Mosby’s Diagnostic & Laboratory Test Reference 12th Edition: Mosby, Inc. Saint Louis, MO. Pp.199-200.

(Updated Oct. 30, 2015) Gentry George T King, M.D. CA 125: Reference Range, Interpretation, Collection and Panels. Available online at http://emedicine.medscape.com/article/2087557-overview. Accessed 23/2016.

Ovarian Cancer National Alliance. Risk Factors. Available online at http://www.ovariancancer.org/about/risk-factors. Accessed 2/8/2016.

Ovarian Cancer National Alliance. Symptoms and Detection of Ovarian Cancer. Available online at http://www.ovariancancer.org/about/symptoms-of-ovarian-cancer-detection. Accessed 2/8/2016.

(Updated 13 January 2016) CA-125 blood test. MedlinePlus Medical Encyclopedia. Available online at https://www.nlm.nih.gov/medlineplus/ency/article/007217.htm. Accessed 2/3/2016.

(©2016) Mayo Clinic Mayo Medical Laboratories. Human Epididymis Protein 4, Serum. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62137. Accessed 2/10/2016.

Ovarian Cancer Testing: HE4 Ovarian Cancer Monitoring. Quest Diagnostics. Available online at http://www.questdiagnostics.com/home/patients/tests-a-z/ovarian-cancer/he4-monitoring.html. Accessed Feb 2016.

(©2014) Laboratory Corporation of America. A Technical Review, Human Epididymis Protein 4 (HE4), Monitoring Patients With Epithelial Ovarian Carcinoma.

(Jan 14, 2015) Fazal Hussain. Gynecologic Tumor Markers, Cancer Antigen 125. Medscape Review. Available online at http://emedicine.medscape.com/article/269839-overview#a2. Accessed 2/8/2016.

(Aug 5, 2014) American Cancer Society. Ovarian Cancer: Detailed Guide. Available online at http://www.cancer.org/cancer/ovariancancer/detailedguide/ovarian-cancer-what-is-ovarian-cancer. Accessed 2/8/2016.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 219-220.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 210-211.

Mason, J. (Updated 2008 June 10). CA-125. MedlinePlus Medical Encyclopedia. [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/007217.htm. Accessed March 2009.

(2007 March). Ovarian Cancer Resource Guide for women with recurrent disease. NOCC, Inc. [On-line information]. PDF available for download at http://www.ovarian.org/Images/ResourceGuideRecurrentOvarianCancer.pdf. Accessed March 2009.

(2008 August 26). Ovarian Cancer: Why Screening Isn't Routine. American Cancer Society. [On-line information]. Available online at http://www.cancer.org/docroot/SPC/content/SPC_1_ovarian_Q_A_Saslow.asp. Accessed March 2009.

(Modified 2008 April 3). Ovarian Cancer Screening (PDQ®), Health Professional Version. NCI, U.S. National Institutes of Health. [On-line information]. Available online at http://www.cancer.gov/cancertopics/pdq/screening/ovarian/healthprofessional. Accessed March 2009.

(2008 July). Understanding CA 125 Levels: A Guide for Ovarian Cancer Patients. Gynecologic Cancer Foundation. [On-line information]. PDF available for download at http://www.thegcf.org/wcnlib/downloads/CA125levels_July2008.pdf. Accessed March 2009.

(Updated 2012 August 1). Fazal Hussain, F. and Homoud, H. Gynecologic Tumor Markers Tumor Marker Overview. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/269839-overview. Accessed October 2012.

Zieve, D. and Chen Y. (Updated 2011 December 15). CA-125. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/007217.htm. Accessed October 2012.

(Revised 2012 October 5). Can ovarian cancer be found early? American Cancer Society [On-line information]. Available online at http://www.cancer.org/cancer/ovariancancer/detailedguide/ovarian-cancer-detection. Accessed October 2012.

Grenache, D. et. al. (Updated 2012 May). Ovarian Cancer. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/OvarianCancer.html?client_ID=LTD. Accessed October 2012.

Schmidt, C. (2011 December 05). CA-125: A Biomarker Put to the Test. Medscape Today News from J Natl Cancer Inst. V 103(17):1290-1281 [On-line information]. Available online at http://www.medscape.com/viewarticle/750770. Accessed October 2012.

Rustin, G. et. al. (2012 March 08). CA-125: To Monitor or Not to Monitor? For Ovarian Cancer Patients in Remission. Medscape Today News [On-line information]. Available online at http://www.medscape.com/viewarticle/759809. Accessed October 2012.

(2012 September). Screening for Ovarian Cancer, U.S. Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information]. Available online at http://www.uspreventiveservicestaskforce.org/uspstf12/ovarian/ovarcancerrs.htm. Accessed November 2012.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 210-211.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 499-500.