Proceeds from website advertising help sustain Lab Tests Online. AACC is a not-for-profit organization and does not endorse non-AACC products and services.

Genetic Tests for Targeted Cancer Therapy

Print this article
Share this page:

Related Pages

On This Site
Tests: Breast Cancer Multiparameter Gene Expression Tests, EGFR Mutation Testing, Her-2/neu, Estrogen/Progesterone Receptor Status, Tumor Markers, BCR-ABL, BRCA Mutation Testing, JAK2 Mutation, KRAS Mutation
Conditions: Breast Cancer, Colon Cancer, Lung Diseases, Lung Cancer, Myeloproliferative Neoplasms, Melanoma
Articles: Universe of Genetic Testing

Elsewhere On The Web
Association for Molecular Pathology
American Cancer Society: Targeted Cancer Therapy
National Cancer Institute: Targeted Cancer Therapies
American Cancer Society: Lung Cancer (Non-Small Cell)
National Cancer Institute: General Information About Non-Small Cell Lung Cancer (NSCLC)
American Cancer Society: Gastrointestinal Stromal Tumor (GIST)
National Cancer Institute: Colorectal Cancer
American Cancer Society: Colorectal Cancer Prevention and Early Detection
MD Anderson Cancer Center: Personalized Cancer Therapy

Article Sources

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

Mahadevan, D. (2015 November 18 Updated). Targeted Cancer Therapy. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/1372666-overview#showall. Accessed on 9/05/16.

(2013 July 12 Revised). Targeted Cancer Therapy. American Cancer Society. Available online at http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/targetedtherapy/index. Accessed on 9/05/16.

(2014 June 12 Revised). The History of Cancer. American Cancer Society. Available online at http://www.cancer.org/acs/groups/cid/documents/webcontent/002048-pdf.pdf. Accessed on 9/05/16.

(2014 April 25 Reviewed). Targeted Cancer Therapies. National Cancer Institute. Available online at http://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet. Accessed on 9/05/16.

Chaturvedi, P. and Wenig, B. (2015 November 23 Updated). Targeted Molecular Therapy in Head and Neck Squamous Cell Carcinoma Overview of Targeted Molecular Therapy in HNSCC. Available online at http://emedicine.medscape.com/article/854971-overview#showall. Accessed on 9/05/16.

Tuazon, S. (2015 September 25 Updated). BRAF Gene Mutation Tests. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/2045309-overview#showall. Accessed on 9/05/16.

Markman, M. (2016 April 26 Updated). Colorectal Cancer and KRAS/BRAF. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/1690010-overview Accessed on 9/05/16.

(2016 June 09 Updated). List of Cleared or Approved Companion Diagnostic Devices (In Vitro and Imaging Tools). US Food and Drug Administration. Available online at http://www.fda.gov/medicaldevices/productsandmedicalprocedures/invitrodiagnostics/ucm301431.htm. Accessed on 9/14/16.

Cagle, P. et. Al (2016). Emerging Biomarkers in Personalized Therapy of Lung Cancer. Adv Exp Med Biol. 2016;890:25-36. doi: 10.1007/978-3-319-24932-2_2. Abstract. Available online at http://www.ncbi.nlm.nih.gov/pubmed/26703797. Accessed on 9/14/16.

Dietel, M. et al (2015 September). A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance. Cancer Gene Ther. 2015 Sep;22(9):417-30. doi: 10.1038/cgt.2015.39. Epub 2015 Sep 11. Abstract. Available online at https://www.ncbi.nlm.nih.gov/pubmed/26358176/. Accessed on 9/14/16.

Abramson, R. 2016. Overview of Targeted Therapies for Cancer. My Cancer Genome (Updated August 8). Available online at https://www.mycancergenome.org/content/molecular-medicine/overview-of-targeted-therapies-for-cancer. Accessed September 2016.

Sources Used in Previous Reviews

Linnea Baudhuin, Phd, DABMG. Assistant Professor of Laboratory Medicine. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

(Revised 2011 November 18). Targeted Cancer Therapies. National Cancer Institute Fact Sheet [On-line information]. Available online at http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted. Accessed March 2012.

Gaughan, E. and Costa, D. (2011 May 19). Genotype-driven Therapies for Non-small Cell Lung Cancer, Focus on EGFR, KRAS and ALK Gene Abnormalities. Medscape Today News from Ther Adv Med Oncol v 3(3):113-125 [On-line information]. Available online at http://www.medscape.com/viewarticle/742530. Accessed March 2012.

Ribas, A. and Flaherty, K. (2011 July 8). BRAF Targeted Therapy Changes the Treatment Paradigm in Melanoma. Nat Rev Clin Onc. 2011;8(7) © Medscape Today News from Nat Rev Clin Onc. v 8(7) [On-line information]. Available online at http://www.medscape.com/viewarticle/744864. Accessed March 2012.

Mahadevan, D. and Talavera, F. (2011 May 16) Targeted Cancer Therapy. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1372666-overview#showall. Accessed March 2012.

Bayon, R. and Chaturvedi, P. (2011 March 29). Targeted Molecular Therapy in Head and Neck Squamous Cell Carcinoma Overview of Targeted Molecular Therapy in HNSCC. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/854971-overview. Accessed March 2012.

(2009 July/August). KRAS Mutation Testing for Anti-Epidermal Growth Factor Receptor Therapy in Colorectal and Lung Cancer. Mayo Clinic Mayo Medical Laboratory Communique [On-line information]. Available online at http://www.mayomedicallaboratories.com/articles/communique/2009/07.html. Accessed May 2012.

Cankovic, M. et. al. (2009 December 8). Clinical Performance of JAK2 V617F Mutation Detection Assays in a Molecular Diagnostics Laboratory: Evaluation of Screening and Quantitation Methods. American Journal of Clinical Pathology v 132(5):713-721. [On-line information]. Available online at http://www.medscape.com/viewarticle/712654. Accessed March 2012.

(Updated 2011 July 8). Colorectal Cancer Trials Support Gene Testing for Two Drugs. National Cancer Institute Fact Sheet [On-line information]. Available online at http://www.cancer.gov/clinicaltrials/results/summary/2008/genetest1108. Accessed March 2012.

Cheson, B. et. al. (2011 November 23). 2011 Top Game Changers in Oncology. Medscape Today News [On-line information]. Available online at http://www.medscape.com/viewarticle/754136. Accessed March 2012.

Corless, C. et. al. (2011 December 31). Gastrointestinal Stromal Tumours Origin and Molecular Oncology. Medscape Today News from Nat Rev Cancer v 11(12):865-878 [On-line information]. Available online at http://www.medscape.com/viewarticle/754503. Accessed March 2012.

Markman, M. (Updated 2011 November 29). Genetics of Non-Small Cell Lung Cancer. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1689988-overview. Accessed March 2012.

Cook, J. et. al. (Updated 2011 July). Gastrointestinal Stromal Tumors – GIST. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/GIST.html?client_ID=LTD. Accessed March 2012.

Lyon, E. et. al. (Updated 2011 July). 5-Fluorouracil Sensitivity. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/5FU.html. Accessed March 2012.

Lyon, E. et. al. (Updated 2011 April). UGT1A1 Genotyping – Irinotecan. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Irinotecan.html. Accessed March 2012.

Turner, J. et. al. (2010 December 17). KRAS Mutation Testing for Colorectal Cancer (CRC). CAP [On-line information]. Available online through http://www.cap.org. Accessed March 2012.

Test ID: FLCA Lung Cancer, ALK (2p23) Rearrangement, FISH, Tissue. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/60619. Accessed March 2012.

Lyon, E. et. al. (Updated 2011 April). CYP2D6 Genotyping – Tamoxifen. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Tamoxifen.html. Accessed March 2012.

Jarboe, E. et. al. (Updated 2011 February). Colorectal Cancer. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/ColorectalCancer.html#tabs=0. Accessed March 2012.

Johnson-Davis, K. and McMillin, G. (Updated 2011 August). Pharmacogenetics – PGx. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/PGx.html?client_ID=LTD#tabs=0. Accessed March 2012.

Kelland, K. (2012 March 7). Cancer gene mutation more complex than previously thought: study. MedlinePlus from Reuters Health [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/news/fullstory_122697.html. Accessed March 2012.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 602-603

(©2012) American Cancer Society. Treatment Types. Available online at http://www.cancer.org/Treatment/TreatmentsandSideEffects/TreatmentTypes/index. Accessed April 2012.

(©2012) American Cancer Society. Targeted Therapy. Available online at http://www.cancer.org/Treatment/TreatmentsandSideEffects/TreatmentTypes/TargetedTherapy/index. Accessed April 2012.

« Prev