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Cyclic Citrullinated Peptide Antibody

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Also known as: CCP Antibody; Citrulline Antibody; Anti-citrulline Antibody; Anti-cyclic Citrullinated Peptide; Anti-CCP; ACPA
Formal name: Cyclic Citrullinated Peptide Antibody

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Reviewer May 2015 Erin Kaleta, PhD, DABCC, Clinical Director, Sonora Quest Laboratories.

(October 2003) Kavanaugh, A., Matteson, E., Cush, J. The Use of anti-cyclic citrullinated peptide (anti-CCP) antibodies in RA, Hotline from the American College of Rheumatology. Available online at https://www.rheumatology.org/publications/hotline/1003anticcp.asp through https://www.rheumatology.org. Accessed on May 11, 2015.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th ed. Curtis, C.A., Ashwood, E.R., Bruns, D.E., eds. St. Louis: Elsevier Saunders.

Aletaha, D., Neogi, T., Silman, A.J., Funovitz, J., Felson, D.T., Bingham, C.O., et al. 2010 Rheumatoid Arthritis Classification Criteria. Arthritis & Rheumatism 62(9), 2569-2581.

Singh, J.A., Furst, D.E., Bharat, A., Curtis, J., Kavangaugh, A.F., Kremer, J.M. 2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying anti-rheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care & Research 64(5), 625-639.

Taylor, P.C., Maini, R.N. Clinically useful biologic markers in the diagnosis and assessment of outcome in rheumatoid arthritis. In: UpToDate, O’Dell, J.R., Romain, P.L., eds. UpToDate, Waltham, MA. Accessed on May 12, 2015.

Sources Used in Previous Reviews

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Shiel, W. (2004 September 17, Reviewed). Citrulline Antibody. MedicineNet.com [On-line information]. Available online at http://www.medicinenet.com/citrulline_antibody/article.htm through http://www.medicinenet.com.

Check, W. (2003 June). Assay takes arthritis out of the gray zone. College of American Pathologists, Feature Story [On-line journal]. Available online at http://www.cap.org/apps/docs/cap_today/feature_stories/rheumarthritis_assay.html through http://www.cap.org.

Bizzarola, N. et. al. (2001). Diagnostic Accuracy of the Anti-Citrulline Antibody Assay for Rheumatoid Arthritis. Clinical Chemistry. 2001; 47:1089-1093. [On-line information]. Available online at http://www.clinchem.org/cgi/content/full/47/6/1089 through http://www.clinchem.org.

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McCoy, T. (2003 October 24). Simple Blood Test May Predict The Development Of Rheumatoid Arthritis In Patients With Joint Pain. American College of Rheumatology, Arthritis News [On-line press release]. Available online at http://www.rheumatology.org/press/2003/pr1.asp through http://www.rheumatology.org.

Bas, S. et. al. (2002). Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors. Rheumatology 2002; 41: 809-814. [On-line journal]. Available online at http://rheumatology.oupjournals.org/cgi/content/full/41/7/809 through http://rheumatology.oupjournals.org.

Vallbracht, I., et. al. (2004). Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis. Annals of the Rheumatic Diseases 2004;63:1079-1084. [On-line abstract]. Available online at http://ard.bmjjournals.com/cgi/content/abstract/63/9/1079 through http://ard.bmjjournals.com.

Castelar Pinheiro, G., et. al. (2003 August 5). Anti–Cyclic Citrullinated Peptide Antibodies in Advanced Rheumatoid Arthritis. Annals of Internal Medicine, Letter, Volume 139 Issue 3, Pages 234-235. [On-line journal]. Available online at http://www.annals.org/cgi/content/full/139/3/234-a through http://www.annals.org.

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Rauscher, M. (2003 October 28, Updated). Antibodies may help predict rheumatoid arthritis. MedicineNet.com, Reuters Health [On-line information]. Available online at http://www.medicinenet.com/script/main/art.asp?articlekey=25015 through http://www.medicinenet.com.

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van der Helm-van Mil, A. et. al. (2005 June 30). Antibodies to Citrullinated Proteins and Differences in Clinical Progression of Rheumatoid Arthritis. Medscape from Arthritis Res Ther. 2005;7(5):R949-R958 [On-line information]. Available online at http://www.medscape.com/viewarticle/507248 through http://www.medscape.com. Accessed on 8-26-08.

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