2. Can platelet function assays be used to assess clopidogrel response?
There are several platelet function assays that have been used for detecting nonresponse (termed "clopidogrel resistance") (e.g., platelet aggregometry with ADP, with collagen epinephrine); however, their clinical utility has not been widely accepted due to poor agreement between the assays.
3. Should everyone be tested for CYP2C19 gene variations?
Testing is not recommended to screen the general population. It is currently only indicated for those taking a drug that may be influenced by the activity of the CYP2C19-related enzymes. In some cases, a doctor may recommend that family members of a poor metabolizer consider testing so that this information is on record.
4. Can clopidogrel resistance testing be done in my doctor's office?
No, it requires specialized equipment to perform and expertise to interpret. It is not offered by every laboratory and may need to be sent to a laboratory outside of your hospital (i.e., reference laboratory).
6. Should I tell my doctors that I am taking clopidogrel?
Yes, it is crucial for you to tell all of your doctors and your dentist that you are taking clopidogrel, aspirin, or another antiplatelet agent. They will need to incorporate this information into any other treatments or procedures.
This article was last reviewed on December 7, 2011. | This article was last modified on January 7, 2014.
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