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WBC Differential

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Also known as: Leukocyte Differential Count; Peripheral Differential; WBC Count Differential; Diff
Formal name: White Blood Cell Differential

A WBC differential typically includes the following: absolute neutrophil count or % neutrophils, absolute lymphocyte count or % lymphocytes, absolute monocyte count or % monocytes, absolute eosinophil count or % esosinophils, and absolute basophil count or % basophils.

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Harmening D. Clinical Hematology and Fundamentals of Hemostasis, Fifth Edition, F.A. Davis Company, Philadelphia, 2009, Pp 305-328.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 547-559.

Wintrobe's Clinical Hematology. 12th ed. Greer J, Foerster J, Rodgers G, Paraskevas F, Glader B, Arber D, Means R, eds. Philadelphia, PA: Lippincott Williams & Wilkins: 2009, Pp 170-402, 1528-1533.

(Feb 1 2011) National Heart Lung Blood Institute. What is lymphocytopenia? Available online at http://www.nhlbi.nih.gov/health/health-topics/topics/lym/ through http://www.nhlbi.nih.gov. Accessed April 2012.

(Jan 23 2012) American Cancer Society. Acute Lymphocytic Leukemia. Available onlne at http://www.cancer.org/Cancer/Leukemia-AcuteLymphocyticALLinAdults/DetailedGuide/leukemia-acute-lymphocytic-what-is-all through http://www.cancer.org. Accessed April 2012.

(Dec 7 2010) American Cancer Society. Acute Myeloid Leukemia. Available online at http://www.cancer.org/Cancer/Leukemia-AcuteMyeloidAML/DetailedGuide/leukemia-acute-myeloid-myelogenous-what-is-aml through http://www.cancer.org. Accessed April 2012.

(Oct 25 2010) American Cancer Society. Non-Hodgkin Lymphoma. Available online at http://www.cancer.org/Cancer/Non-HodgkinLymphoma/DetailedGuide/non-hodgkin-lymphoma-what-is-non-hodgkin-lymphoma through http://www.cancer.org. Accessed April 2012.

(January 8 2010) Kempert P. White Blood Cell Function, Overview of the Immune System. Medscape Reference article. Available online at http://emedicine.medscape.com/article/960027-overview through http://emedicine.medscape.com. Accessed April 2012.

(January 26, 2010) Naushad H. Leukocyte Count (WBC). Medscape Reference article. Available online at http://emedicine.medscape.com/article/2054452-overview#aw2aab6b2 through http://emedicine.medscape.com. Accessed April 2012.

(Updated December 5, 2011) Nader N. Neutrophilia. Medscape Reference article. Available online at http://emedicine.medscape.com/article/208576-overview through http://emedicine.medscape.com. Accessed April 2012.

(May 24, 2011) Godwin J. Neutropenia. Medscape Reference article. Available online at http://emedicine.medscape.com/article/204821-overview through http://emedicine.medscape.com. Accessed April 2012.

(August 25, 2011) Liss M. Eosinophilia. Medscape Reference article. Available online at http://emedicine.medscape.com/article/199879-overview through http://emedicine.medscape.com. Accessed April 2012.

(January 14, 2015) Curry C. White Blood Cell Differential. Medscape Reference. Available online at http://emedicine.medscape.com/article/2085133-overview#a2 through http://emedicine.medscape.com. Accessed July 10, 2015.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Susan J. Leclair, PhD, CLS(NCA). Professor of Medical Laboratory Science, Department of Medical Laboratory Science, University of Massachusetts, Dartmouth, MA.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 1003-1008.