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Direct LDL Cholesterol

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Also known as: Direct LDL-C; Direct LDL; DLDL; LDL D
Formal name: Direct Low-Density Lipoprotein Cholesterol

The Test Sample

What is being tested?

The direct low-density lipoprotein cholesterol test (direct LDL-C) measures the amount of LDL cholesterol, sometimes called "bad" cholesterol, in the blood. Elevated levels of LDL-C are associated with an increased risk of hardening of the arteries (atherosclerosis) and heart disease. Usually, the amount of LDL-C is calculated using the measured values (cholesterol, HDL-C, and triglycerides) from a standard lipid profile. In most cases, this is a good estimate of the LDL-C, but it becomes less accurate with increasing triglyceride levels. Direct measurement of LDL-C is less affected by triglycerides and can be used when triglycerides are high (above 400 mg/dl).

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in the arm.

NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.

Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is needed; however, a health practitioner may request fasting.