Proceeds from website advertising help sustain Lab Tests Online. AACC is a not-for-profit organization and does not endorse non-AACC products and services.

Protein Electrophoresis
Immunofixation Electrophoresis

Print this article
Share this page:
Also known as: Serum Protein Electrophoresis; Protein ELP; SPE; SPEP; Urine Protein Electrophoresis; UPE; UPEP; IFE; CSF Protein Electrophoresis
Formal name: Protein Electrophoresis; Immunofixation Electrophoresis

Article Sources

« Return to Related Pages

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Tuazon, S. A. and Scarpaci, A. (Updated 2014 September 5). Serum Protein Electrophoresis. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/2087113-overview through http://emedicine.medscape.com. Accessed November 2014.

Dimou, A. and Leighton, J. Immunofixation. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/2086976-overview through http://emedicine.medscape.com. Accessed November 2014.

Gersten, T. (Updated 2014 February 24). Protein electrophoresis – serum. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003540.htm through http://www.nlm.nih.gov. Accessed November 2014.

Chen, Y.B. (Updated 2014 May 29). Protein electrophoresis – urine. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003589.htm through http://www.nlm.nih.gov. Accessed November 2014.

(© 1995–2014). Electrophoresis, Protein, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/80085 through http://www.mayomedicallaboratories.com. Accessed November 2014.

Delgado, J. et. al. (Updated 2014 August). Plasma Cell Dyscrasias. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/PlasmaCellDyscrasias.html?client_ID=LTD through http://www.arupconsult.com. Accessed November 2014.

McTaggart, M. et. al. (2013). Replacing Urine Protein Electrophoresis With Serum Free Light Chain Analysis as a First-line Test for Detecting Plasma Cell Disorders Offers Increased Diagnostic Accuracy and Potential Health Benefit to Patients. Am J Clin Pathol. v140 (6):890-897 [On-line information]. Available online at http://www.medscape.com/viewarticle/818733 through http://www.medscape.com. Accessed November 2014.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Spengler, Renee (2002 September 5, Updated). LaurusHealth.com Health Library, Medical Tests [On-line information]. Available online

Thomson Corporation (2002). Immunoelectrophoresis. Hendrick Health System, AccessMed Health Information Library [On-line information]. Available online through http://www.ehendrick.org/healthy/

Thomson Corporation (2002). Protein Electrophoresis. Hendrick Health System, AccessMed Health Information Library [On-line information]. Available online through http://www.ehendrick.org/healthy/

Thomson Corporation (2003 January 28). Immunoelectrophoresis. BluePrint for Health, BC/BS of Minnesota [On-line information]. Available online at http://blueprint.bluecrossmn.com/topic/topic100587005 through http://blueprint.bluecrossmn.com.

Immunofixation Electrophoresis, Quantitative. ARUP's Guide to Clinical Laboratory Testing (CLT) [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_al4b.htm#1152005 through http://www.aruplab.com.

Protein Electrophoresis. ARUP's Guide to Clinical Laboratory Testing (CLT) [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_155b.htm#1145652 through http://www.aruplab.com.

Elstrom, R. (2001 October 21, Updated). Immunoelectrophoresis - serum. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003541.htm.

Elstrom, R. (2001 November 3, Updated). Immunoelectrophoresis - urine. MedlinePlus Medical Encyclopedia [On-line information]. Available online a http://www.nlm.nih.gov/medlineplus/ency/article/003592.htm.

Elstrom, R. (2001 October 21, Updated). Protein electrophoresis - serum. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003540.htm.

Elstrom, R. (2001 November 3, Updated). Protein electrophoresis - urine. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003589.htm.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp. 775-780.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp. 197-210.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp. 922-926.

Nanda, R. (2007 March 8, Updated). Protein electrophoresis serum. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003540.htm. Accessed on 9/09/07.

(2005 January 1). OConnell, T. et. al. Understanding and Interpreting Serum Protein Electrophoresis. American Family Physician 2005;71(1):105-112 [On-line journal article]. Available online at http://www.aafp.org/afp/20050101/105.html through http://www.aafp.org. Accessed on 9/09/07.

Lonial, S. (2005 September 9, Reviewed). Multiple Myeloma Diagnosis and Staging. Multiple Myeloma Research Foundation [On-line information]. Available online at http://www.multiplemyeloma.org/about_myeloma/2.05.php through http://www.multiplemyeloma.org. Accessed on 9/09/07.

Dugdale III, D. (Updated 2010 February 5). Protein electrophoresis – serum. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003540.htm. Accessed May 2011.

Dugdale III, D. (Updated 2011 January 24). Protein electrophoresis – urine. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003589.htm. Accessed May 2011.

Rogoski, R. (2009 July). Serum free light chain assays: Detecting plasma cell disorders. Medical Laboratory Observer [On-line information]. Available online at http://www.mlo-online.com/features/2009_july/0709_coverstory.aspx through http://www.mlo-online.com. Accessed May 2010.

(© 1995–2010). Unit Code 80085: Electrophoresis, Protein, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/80085 through http://www.mayomedicallaboratories.com. Accessed May 2011.

Wood, P. et. al. (2010 November 8). Comparison of Serum Immunofixation Electrophoresis and Free Light Chain Assays in the Detection of Monoclonal Gammopathies. Medscape Today from Clin Lymphoma Myeloma. 2010;10(4):278-280 [On-line information]. Available online at http://www.medscape.com/viewarticle/729328 through http://www.medscape.com. Accessed May 2011.

(©2006-2010). Protein Electrophoresis, CSF : 0050590. ARUP's Laboratory Test Directory. [On-line information]. Available online at http://www.aruplab.com/guides/ug/tests/0050590.jsp through http://www.aruplab.com. Accessed May 2011.

O'Connell T, Horita T, Kasravi B. Understanding and Interpreting Protein Electrophoresis. Am Fam Physician 2005 Jan 1;71(1):105-112. Available online at http://www.aafp.org/afp/2005/0101/p105.html through http://www.aafp.org. Accessed May 2011.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. Chapter 17, Pp 89-91.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 232-233, 241-242, 400, 843-846.