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Estimated Glomerular Filtration Rate (eGFR)

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Also known as: Glomerular Filtration Rate, Estimated; GFR; eGFR; Calculated Glomerular Filtration Rate; cGFR
Formal name: Estimated Glomerular Filtration Rate

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

(2016) National Kidney Foundation. GFR Calculator. Available online at https://www.kidney.org/professionals/KDOQI/gfr_calculator. Accessed June 19, 2016.

(2014) National Kidney Foundation. Frequently Asked Questions about GFR Estimates. Available online at https://www.kidney.org/sites/default/files/docs/12-10-4004_abe_faqs_aboutgfrrev1b_singleb.pdf. Accessed June 19, 2016.

(April 2015) National Institute of Diabetes and Digestive and Kidney Diseases. Estimating Glomerular Filtration Rate (GFR). Available online at http://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/lab-evaluation/gfr/estimating/Pages/estimating.aspx#the-mdrd-equation. Accessed June 20, 2016.

(April 2015) Medscape. Chronic Kidney Disease Workup. Available online at http://emedicine.medscape.com/article/238798-workup#c8. Accessed June 23, 2016.

NFK KDOQI Guidelines. Available online at http://www2.kidney.org/professionals/KDOQI/guidelines_ckd/p4_class_g1.htm. Accessed June 2016.

Mayo Clinic. Creatinine with Estimated GFR (MDRD), Serum. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/8472. Accessed June 2016.

Mayo Clinic. Interpretive Handbook. Test 8472: Creatinine with Estimated GFR (MDRD), Serum. Available online at http://www.mayomedicallaboratories.com/interpretive-guide/?alpha=C&unit_code=8472. Accessed June 2016.

NIH National Institute of Diabetes and Digestive and Kidney Diseases. Estimating Glomerular Filtration Rate (GFR). Available online at http://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/lab-evaluation/gfr/estimating/Pages/estimating.aspx. Accessed June 2016.

NIH National Institute of Diabetes and Digestive and Kidney Diseases. Reporting Glomerular Filtration Rate (GFR). Available online at http://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/lab-evaluation/gfr/reporting/Pages/reporting.aspx. Accessed June 2016.

American Kidney Fund. Tests for kidney health. Available online at http://www.kidneyfund.org/prevention/tests-for-kidney-health/?referrer=https://www.google.com/. Accessed June 2016.

American Kidney Fund. Blood test: eGFR. Available online at http://www.kidneyfund.org/prevention/tests-for-kidney-health/egfr-test.html. Accessed June 2016.

Quest Diagnostics. Test Center: Creatinine-based Estimated Glomerular Filtration Rate (eGFR). Available online at http://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_eGFR. Accessed June 2016.

Sources Used in Previous Reviews

National Kidney Foundation. DOQI: Clinical Practice Guidelines. Available online at http://www.kidney.org/professionals/kdoqi/guidelines.

National Kidney Foundation. Glomerular Filtration Rate. Available online at http://www.kidney.org/kidneydisease/ckd/knowGFR.cfm.

National Kidney Foundation. Kidney Learning System: GFR. Available online at http://www.kidney.org/professionals/KLS/gfr.cfm.

Levey et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Annals of Internal Medicine. 1999; 130(6):461-470.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 311-312.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 438-439.

Patel, P. (Updated 2009 August 12). Glomerular filtration rate. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/007305.htm. Accessed October 2009.

(2009 February). The Kidneys and How They Work. National Kidney and Urologic Diseases Information Clearinghouse [On-line information]. Available online at http://kidney.niddk.nih.gov/kudiseases/pubs/yourkidneys/. Accessed October 2009.

(Reviewed 2009 April 7). Laboratory Professionals, Estimating and Reporting GFR. National Kidney Disease Education Program [On-line information]. Available online at http://www.nkdep.nih.gov/labprofessionals/estimate_report_gfr.htm. Accessed October 2009.

Delgado, J. (Updated 2009 August). Renal Function Markers - Kidney Disease. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/RenalFunctionMarkers.html?client_ID=LTD#. Accessed October 2009.

(© 2007). Estimated Glomerular Filtration Rate (eGFR), in the Detection and Assessment of Chronic Kidney Disease in Adults. LabCorp Technical Review [On-line information]. PDF available for download at https://www.labcorp.com/pdf/Estimated_Glomerular_Filtration_Rate_eGFRL1137_1207_2.pdf. Accessed October 2009.

(Reviewed 2007 October). Glomerular Filtration Rate, Estimated (eGFR). Quest Diagnostics Test Summary [On-line information]. Available online at http://www.questdiagnostics.com/hcp/intguide/jsp/showintguidepage.jsp?fn=TS_eGFR.htm. Accessed October 2009.

Turin, T. et. al. (2013) Change in the Estimated Glomerular Filtration Rate Over Time and Risk of All-Cause Mortality. Medscape Today News from Kidney Int. v83 (4):684-691 [On-line information]. Available online at http://www.medscape.com/viewarticle/782622. Accessed July 2013.

Simon, J. et. al. (2011 March). Interpreting the estimated glomerular filtration rate in primary care: Benefits and pitfalls. Cleveland Clinic Journal of Medicine v78 (3) 189-195. [On-line information]. Available online at http://www.ccjm.org/content/78/3/189.full. Accessed July 2013.

(© 1995–2013). Cystatin C with Estimated GFR, Serum. Mayo Clinic Mayo Medical Laboratory Interpretive Handbook [On-line information]. Available online at http://www.mayomedicallaboratories.com/interpretive-guide/?alpha=C&unit_code=35038. Accessed July 2013.

(Updated 2012 July 10) For People with Diabetes or High Blood Pressure: Get Checked for Kidney Disease. National Kidney Disease Education Program [On-line information]. Available online at http://www.nkdep.nih.gov/resources/get-checked-kidney-disease.shtml. Accessed July 2013.

Dugdale, D. (Updated 2011 September 19). Glomerular filtration rate. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/007305.htm. Accessed July 2013.

Shah, A. (Revised 2013 May). Evaluation of the Renal Patient. Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed July 2013.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 329-333.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 362-364.

McPherson, R. and Pincus, M. (© 2011). Henry's Clinical Diagnosis and Management by Laboratory Methods 22nd Edition: Elsevier Saunders, Philadelphia, PA. Pp 173-177.

National Kidney Disease Education Program. Estimating GFR. Available online at http://nkdep.nih.gov/lab-evaluation/gfr/estimating.shtml. Accessed October 2013.

National Kidney Foundation. Cystatin C: What is its role in estimating GFR? Available online at http://www.kidney.org/professionals/tools/pdf/CystatinC.pdf. Accessed October 2013.

Weber, CL et al. Demystifying chronic kidney disease: Clinical caveats for the family physician. BCMJ, Vol. 50, No. 6, July, August 2008, page(s) 304-309. Available online at http://www.bcmj.org/article/demystifying-chronic-kidney-disease-clinical-caveats-family-physician. Accessed January 2015.