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Heparin Anti-Xa

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Also known as: Anti-Xa; Xa Inhibition; Anti-factor Xa Heparin; Anti-FXa; Heparin Level; Heparin Activity
Formal name: Heparin Anti-Xa

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Harmening D. Clinical Hematology and Fundamentals of Hemostasis, Fifth Edition, F.A. Davis Company, Philadelphia, 2009, Pp 862-863, 584-585, 685-686.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 780-781.

(© 1995-2011). Unit Code 80609: Heparin Anti-Xa Assay, Plasma. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/80609 through http://www.mayomedicallaboratories.com. Accessed November 2011.

Smith, M. and Wheeler, K. (2010 May 6). Weight-based Heparin Protocol using Antifactor Xa Monitoring. Medscape Today News from American Journal of Health-System Pharmacy. 2010;67(5):371-374. [On-line information]. Available online at http://www.medscape.com/viewarticle/720025 through http://www.medscape.com. Accessed November 2011.

Guervil, D. et. al. (2011 August 9). Activated Partial Thromboplastin Time versus Antifactor Xa Heparin Assay in Monitoring Unfractionated Heparin by Continuous Intravenous Infusion. Medscape Today News from The Annals of Pharmacotherapy. 2011;45(8):861-868 [On-line information]. Available online at http://www.medscape.com/viewarticle/746710 through http://www.medscape.com. Accessed November 2011.

Shapiro, N. et. al. (2011 August 1). Dosing and Monitoring of Low-molecular-weight Heparin in High-risk Pregnancy Single-Center Experience. Medscape Today News from Pharmacotherapy. 2011;31(7):678-685 [On-line information]. Available online at http://www.medscape.com/viewarticle/746233 through http://www.medscape.com. Accessed November 2011.

Lehman, C. and Frank, E. (2009 January). Laboratory Monitoring of Heparin Therapy: Partial Thromboplastin Time or Anti-Xa Assay? ASCP LabMedicine, 40, 47-51 [On-line information]. Available online at http://labmed.ascpjournals.org/content/40/1/47.full through http://labmed.ascpjournals.org. Accessed November 2011.

Sources Used in Previous Reviews

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp 233-234.

Tahir, R. (2007 July 13). A Review of Unfractionated Heparin and Its Monitoring. U.S. Pharm. 2007:32(7) [On-line information]. Available online at http://www.uspharmacist.com/index.asp?show=article&page=8_2073.htm through http://www.uspharmacist.com. Accessed on 6/1/08.

(2008 January, Updated). Heparin and Anti-Xa Assays]. Clot-ED [On-line information]. Available online at http://www.clot-ed.com/edit/ask_expert.html through http://www.clot-ed.com. Accessed on 6/1/08.

Schick, P. and Schick, B. (2007 April 30). Hypercoagulability: Hereditary Thrombophilia and Lupus Anticoagulants Associated with Venous Thrombosis and Emboli. emedicine [On-line information]. Available online at http://www.emedicine.com/med/TOPIC3776.HTM through http://www.emedicine.com. Accessed on 6/1/08.

O’Donnell, M. et. al. (© 2007). Brief Communication: Preoperative Anticoagulant Activity after Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin. Annals of Internal Medicine 2007;146:184-187. [On-line information]. Available online at http://www.annals.org/cgi/eletters/146/3/184 through http://www.annals.org. Accessed on 6/1/08.

Coon, D. and Hamachi-Lopez, M. (2007 January 8). New Test Announcement, Antifactor Xa Assay. CLH Technical Bulletin 07-003 [On-line information]. PDF available for download at http://www.clhlab.com/attachment/624F6C540986B6E9E7F65D1391/LMWH.pdf through http://www.clhlab.com. Accessed on 6/1/08.

Baglin, T. et. al. (© 2006) Guidelines on the use and monitoring of heparin. British Society for Haematology v(133) 19-34. [On-line information]. PDF available for download at http://www.bcshguidelines.com/pdf/heparin_220506.pdf through http://www.bcshguidelines.com. Accessed on 6/1/08.

McGlasson, D. (2005 May 25). Using a Single Calibration Curve With the Anti-Xa Chromogenic Assay for Monitoring Heparin Anticoagulation. Lab Med. 2005;36(5):297-299. [On-line information]. Available online at http://www.medscape.com/viewarticle/504792 through http://www.medscape.com. Accessed on 6/1/08.

Hirsh, J. and Raschke, R. (© 2004). Heparin and Low-Molecular-Weight Heparin: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. CHEST 2004;126;188-203. [On-line information]. Available online at http://www.chestjournal.org/cgi/content/full/126/3_suppl/188S through http://www.chestjournal.org. Accessed on 6/1/08.

Duplaga, B. et. al. (© 2001). Dosing and Monitoring of Low-Molecular-Weight Heparins in Special Populations. Medscape from Pharmacotherapy 21(2):218-234. [On-line information]. Available online at http://www.medscape.com/viewarticle/409676 through http://www.medscape.com. Accessed on 6/1/08.

Yeager, B. and Matheny, S. (1999 February 15). Low-Molecular-Weight Heparin in Outpatient Treatment of DVT. American Family Physician [On-line information]. Available online at http://www.aafp.org/afp/990215ap/945.html through http://www.aafp.org. Accessed on 6/1/08.