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Hepatitis C Testing

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Also known as: Hepatitis C Antibody; Anti-HCV; HCV-PCR; HCV-RNA; Hepatitis C Viral Load
Formal name: Viral Hepatitis C Antibody Screen; Viral Hepatitis C RNA by PCR; Hepatitis C Virus Genotype

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

(© 2009) Ghany M, et al. Diagnosis, Management and Treatment of Hepatitis C, An Update. Hepatology, the American Association for the Study of Liver Diseases Practice Guidelines. Available online through http://www.aasld.org. Accessed July 2013.

(May 10, 2013) Centers for Disease Control and Prevention. Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians. MMWR May 10, 2013 / 62(18);362-365. Available online at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6218a5.htm through http://www.cdc.gov. Accessed June 2013.

(2013) Centers for Disease Control and Prevention. Interpretation of Results of Tests for Hepatitis C Virus (HCV) Infection and Further Actions. PDF available for download at http://www.cdc.gov/hepatitis/HCV/PDFs/hcv_graph.pdf through http://www.cdc.gov. Accessed June 2013.

(1999) U.S. Food and Drug Administration. Device Approvals and Clearances. Home Access Hepatitis C Checksm and Hepatitis C Checksm Express. Available online at http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfTopic/pma/pma.cfm?num=P980046 through http://www.fda.gov. Accessed June 2013.

Fischbach, F.T. (2004). A Manual of Laboratory & Diagnostic Tests. 7th Edition., Lippincott Williams & Wilkins, Philadelphia.

(July 8, 2008) Centers for Disease Control and Prevention. Hepatitis C Information for Professionals. Available online at http://www.cdc.gov/hepatitis/HCV/index.htm through http://www.cdc.gov. Accessed July 2013.

(July 21, 2008) Centers for Disease Control and Prevention. Hepatitus C FAQs for Professionals. Available online at http://www.cdc.gov/hepatitis/HCV/HCVfaq.htm through http://www.cdc.gov. Accessed July 2013.

(May 10, 2013) Centers for Disease Control and Prevention. Vital Signs: Evaluation of Hepatitis C Virus Infection Testing and Reporting — Eight U.S. Sites, 2005–2011. MMWR 62(18);357-361. Available online at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm62e0507a1.htm?s_cid=mm62e0507a1_w through http://www.cdc.gov. Accessed May 14, 2013.

Ly K, et al. The Increasing Burden of Mortality From Viral Hepatitis in the United States Between 1999 and 2007. Ann Intern Med, February 21, 2012 vol. 156 no. 4 271-278. Available online http://www.annals.org/content/156/4/271.full through http://www.annals.org through http://www.annals.org. Accessed July 2013.

Rein D, et al. The Cost-Effectiveness of Birth-Cohort Screening for Hepatitis C Antibody in U.S. Primary Care Settings. Ann Intern Med, February 21, 2012, vol. 156 no. 4, 263-269. Available online at http://www.annals.org/content/156/4/263-270 through http://www.annals.org through http://www.annals.org. Accessed July 2013.

Alter HJ, Liang TJ. Hepatitis C. The End of the Beginning and Possibly the Beginning of the End. Ann Intern Med, February 21, 2012, vol 156 no. 4, 317-318. Available online at http://www.annals.org/content/156/4/317 through http://www.annals.org. Accessed July 2013.

Makiko Kitamura (Mar 14, 2012). Former Merck Unit Works on First Vaccine for Hepatitis C. Bloomberg. Available online at http://www.bloomberg.com/news/2012-03-14/former-merck-unit-works-on-first-vaccine-for-hepatitis-c.html through http://www.bloomberg.com. Accessed July 2013.

Centers for Disease Control and Prevention. Recommendations for the Identification of Chronic Hepatitis C Virus Infection Among Persons Born During 1945–1965. Prepared by Smith, Bryce D. et al. MMWR. August 17, 2012. Available online at http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6104a1.htm?s_cid=rr6104a1_w through http://www.cdc.gov. Accessed July 2013.

Sources Used in Previous Reviews

Clinical Chemistry: Principles, Procedures, Correlations. Michael L. Bishop, Janet L. Duben-Engelkirk, Edward P. Fody. Lipincott Williams & Wilkins, 4th Edition.

The Hepatitis Information Network. Diagnostic Tests for Hepatitis C. By David Gretch, MD, PhD. Available online at http://www.hepnet.com/nih/gretch.html through http://www.hepnet.com.

(Updated 2009 June 9). Hepatitis C FAQs for the Public. CDC [On-line information]. Available online at http://www.cdc.gov/hepatitis/C/cFAQ.htm#overview through http://www.cdc.gov. Accessed January 2010.

(2009 April). What I need to know about Hepatitis C. National Digestive Diseases Information Clearinghouse [On-line information]. Available online at http://digestive.niddk.nih.gov/ddiseases/pubs/hepc_ez/index.htm through http://digestive.niddk.nih.gov. Accessed January 2010.

(Updated 2009 December 16). Hepatitis C: For Patients and the Public. United States Department of Veterans Affairs [On-line information]. Available online at http://www.hepatitis.va.gov/vahep?page=pt-home through http://www.hepatitis.va.gov. Accessed January 2010.

Hillyard, D. and Slev, P. (Updated 2009 November). Hepatitis C Virus – HCV. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/HCV.html?client_ID=LTD through http://www.arupconsult.com. Accessed January 2010.

Mayo Clinic Staff (2009 September 12). Hepatitis C. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/hepatitis-c/DS00097/METHOD=print through http://www.mayoclinic.com. Accessed January 2010.

Ford, A. (2009 April). Singing new tunes for hepatitis testing. CAP Today Feature Story [On-line information]. Available online at http://www.cap.org/apps/portlets/contentViewer/show.do?printFriendly=true&contentReference=cap_today%2F0409%2F0409a_singing_new_tunes.html through http://www.cap.org. Accessed January 2010.

Mukherjee, S. and Dhawan, V. (Updated 2009 June 18). Hepatitis C: Differential Diagnoses & Workup. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/177792-diagnosis through http://emedicine.medscape.com. Accessed January 2010.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 526-530.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 492-493.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 544-547.

(July 8, 2008) Centers for Disease Control and Prevention: Hepatitis C Information for Health Professionals. Available online at http://www.cdc.gov/hepatitis/HCV/index.htm through http://www.cdc.gov. Accessed February 2010.

Davis GL, et al. Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression. Gastroenterology. 2010 Feb;138(2): 513-521.

Sinnema, J. University of Alberta researchers move closer to hepatitis C vaccine. Postmedia News. February 15, 2012. Available online at http://www.canada.com/health/University+Alberta+researchers+move+closer+hepatitis+vaccine/6159502/story.html?id=6159502 through http://www.canada.com. Accessed February 2012.

Centers for Disease Control and Prevention. Recommendations for the Identification of Chronic Hepatitis C Virus Infection Among Persons Born During 1945–1965. Prepared by Smith, Bryce D. et al. MMWR. August 17, 2012. Available online at http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6104a1.htm?s_cid=rr6104a1_w through http://www.cdc.gov. Accessed August 2012.