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HLA-B27

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Also known as: HLA-B27 Antigen; B27
Formal name: Human Leukocyte Antigen B27

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

MedlinePlus Medical Encyclopedia. HLA-B27 antigen. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm. Accessed June 2013.

Di Lorenzo, AL et al. HLA-B27 Syndromes. Medscape Reference. Available online at http://emedicine.medscape.com/article/1201027-overview through http://emedicine.medscape.com. Accessed June 2013.

Reveille JD, Hirsch R, Dillon CF, Carroll MD, Weisman MH. The prevalence of HLA-B27 in the US: data from the US National Health and Nutrition Examination Survey, 2009. Arthritis Rheum. 2012 May;64(5):1407-11. Available online at http://www.ncbi.nlm.nih.gov/pubmed/22139851 through http://www.ncbi.nlm.nih.gov. Accessed June 2013.

MayoClinic.com. Ankylosing Spondylitis. Available online at http://www.mayoclinic.com/health/ankylosing-spondylitis/DS00483/ through http://www.mayoclinic.com. Accessed June 2013. 

Diyarbakir E, Eyerci N, Melikoglu M, Topcu A, Pirim I. HLA B27 subtype distribution among patients with ankylosing spondylitis in eastern Turkey. Genet Test Mol Biomarkers. 2012 May;16(5):456-8. Epub 2012 Mar 21. Available online at http://www.ncbi.nlm.nih.gov/pubmed/22621386 through http://www.ncbi.nlm.nih.gov. Accessed June 2013.

Spondylitis Association of America. About Ankylosing Spondylitis. Available online at http://www.spondylitis.org/about/as.aspx through http://www.spondylitis.org. Accessed June 2013.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Ankylosing spondylitis. Hendrick Health System, AccessMed Online Health Information Library [On-line information]. Available online at http://www.ehendrick.org/healthy/ through http://www.ehendrick.org.

HLA-B27. ARUP's Guide to Clinical Laboratory Testing (CLT) [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a287.htm#1195370 through http://www.aruplab.com.

Diagnosis, Symptoms, and Treatment. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/html/htmlpages.asp?load=diagnosis_what.htm through http://www.spondylitis.org.

Mayo Clinic Staff (2003 June 05). Ankylosing spondylitis. MayoClinic.com, Diseases and Conditions [On-line information. Available online at http://www.mayoclinic.com/invoke.cfm?id=DS00483 through http://www.mayoclinic.com.

Kovacs, B. (2001 November 29, Updated). Reiter's syndrome. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000440.htm.

Milone, M. (2001 November 19, Updated). Histocompatibility antigens. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003550.htm.

Milone, M. (2001 December 5, Updated). HLA-B27 antigen. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm.

(2003 May 21, Updated). Spondylitis: Frequently Asked Questions. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/about/faq.aspx through http://www.spondylitis.org.

(2003 June 19, Updated). Reactive Arthritis/Reiter's Syndrome (ReA), Diagnosis. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/about/reactive/diagnosis.aspx through http://www.spondylitis.org.

Agrawal, S. (2003 August 15). Immunophenotyping using flow cytometry. Express Healthcare Management [On-line Newspaper, India]. Available online at http://www.expresshealthcaremgmt.com/labwatch/lab6.shtml through http://www.expresshealthcaremgmt.com.

Waheed, N. (1998). HLA-B27 Associated Uveitis. Massachusetts Eye & Ear Infirmary, Ocular Immunology & Uveitis Service [On-line information]. Available online at http://www.uveitis.org/Enhanced/MD_info/md_hlab27.htm through http://www.uveitis.org.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp. 544-545.

(© 2007). Ankylosing Spondylitis (AS) Diagnosis. Spondylitis Association of America [On-line information]. Available online at http://www.spondylitis.org/about/as_diag.aspx through http://www.spondylitis.org. Accessed on 9/09/07.

Alexander, D. (2007 May 29, Updated). HLA-B27 antigen. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm. Accessed on 9/09/07.

Thjodleifsson, B. et. al.(2007 July 30). Evidence of a Common Genetic Background for Ankylosing Spondylitis and Inflammatory Bowel Disease. American College of Rheumatology from Arthritis & Rheumatism 2007; (DOI:10.1002/art.22812) [On-line journal article]. Available online at http://www.rheumatology.org/press/2007/0730ankylosing.asp through http://www.rheumatology.org. Accessed on 9/09/07.

(© 2007). Ankylosing Spondylitis. American College of Rheumatology [On-line information]. Available online at http://www.rheumatology.org/public/factsheets/as.asp?aud=pat through http://www.rheumatology.org. Accessed on 9/9/07.

Waheed, N. (© 1996-2006). HLA-B27 Associated Uveitis. The Ocular Immunology and Uveitis Foundation [On-line information]. Available online at http://www.uveitis.org/medical/articles/case/hlab27.html through http://www.uveitis.org. Accessed on 9/09/07.

Dugdale, D. (Updated 2009 May 21). HLA-B27 antigen. MedlinePlus Medical Encyclopedia [On-line information] Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm. Accessed October 2010.

Mayo Clinic Staff (2009 February 3). Ankylosing spondylitis. MayoClinic.com [On-line information] Available online at http://www.mayoclinic.com/print/ankylosing-spondylitis/DS00483/DSECTION=all&METHOD=print through http://www.mayoclinic.com. Accessed October 2010.

Brent, L. and Kalagate, R. (Updated 2010 May 6). Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy. eMedicine On-line information] Available online at http://emedicine.medscape.com/article/332945-overview through http://emedicine.medscape.com. Accessed October 2010.

Altman, R. (Revised 2008 February). Seronegative Spondyloarthropathies (Seronegative Spondyloarthritides). Merck Manual for Healthcare Professionals [On-line information] Available online at http://www.merck.com/mmpe/sec04/ch034/ch034d.html?qt=HLA-B27&alt=sh through http://www.merck.com. Accessed October 2010.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 544-545.

Waheed N. HLA-B27 associated uveitis. Ocular Immunology and Uveitis Foundations, ©2008. Available online at http://www.uveitis.org/medical/articles/case/hlab27.html through http://www.uveitis.org. Accessed Nov 2010.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds (2005). Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 1936-1937, 1993-1997.