2. What signs and symptoms are seen with excess GH and IGF-1 production?
In a child, it is unusual tallness. With an adult, it may be more subtle: a larger nose, thicker lips, a more prominent jaw, or rings and shoes that no longer fit. Other signs and symptoms may include:
Deepened, husky voice
Enlarged organs (liver, heart, kidneys, and spleen)
As long as you are considered to have abnormal (low or high) GH production or are receiving GH replacement therapy, your IGF-1 will need to be monitored. However, IGF-1 is not routinely measured to monitor GH treatment of GH-deficient children. The best index of the effectiveness of GH treatment of children who are GH-deficient is observation of an increase in their growth rate and their absolute height.
This article was last reviewed on March 23, 2015. | This article was last modified on March 23, 2015.
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