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KRAS Mutation

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Also known as: K-Ras
Formal name: KRAS Mutation Analysis

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Lefferts, J. and Tsongalis, G. (2010 March 5). KRAS Mutation Detection: A New Look at an Old Gene. Clinical Chemistry v 56:5, 698–701 [On-line information]. Available online at http://www.clinchem.org/content/56/5/698.full through http://www.clinchem.org. Accessed May 2012.

Franklin, W. et. al. (2012 January). KRAS Mutation Comparison of Testing Methods and Tissue Sampling Techniques in Colon Cancer. J Mol Diagn. v 12(1): 43–50. [On-line information]. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797717/ through http://www.ncbi.nlm.nih.gov. Accessed May 2012.

Anderson, S. (2011 August 15). Laboratory Methods for KRAS Mutation Analysis. Medscape Today News from Expert Rev Mol Diagn. v 11(6):635-642 [On-line information]. Available online at http://www.medscape.com/viewarticle/746638 through http://www.medscape.com. Accessed May 2012.

Markman, M. (Updated 2012 March 28). Colorectal Cancer and KRAS/BRAF. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1690010-overview through http://emedicine.medscape.com. Accessed May 2012.

Pool, M. (2009 March 2). The Role of KRAS Mutation Testing in the Management of Colorectal Cancer. CAP [On-line information]. Available online through http://www.cap.org. Accessed May 2012.

(2009 July). KRAS Mutation Testing for Anti-Epidermal Growth Factor Receptor Therapy in Colorectal and Lung Cancer. Mayo Clinic Mayo Medical Laboratories Communique [On-line information]. Available online at http://www.mayomedicallaboratories.com/articles/communique/2009/07.html through http://www.mayomedicallaboratories.com. Accessed May 2012.

(© 1995-2012). Test ID: KRAS KRAS Gene, 7 Mutation Panel, Tumor. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89378 through http://www.mayomedicallaboratories.com. Accessed May 2012.

Jarboe, E. et. al. (Updated 2011 February). Colorectal Cancer. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/ColorectalCancer.html through http://www.arupconsult.com. Accessed May 2012.

(Reviewed 2012 May). KRAS. Genetics Home Reference [On-line information]. Available online at http://ghr.nlm.nih.gov/gene/KRAS through http://ghr.nlm.nih.gov/gene/KRAS. Accessed May 2012.

(Reviewed 2011 December 7). Tumor Markers. National Cancer Institute [On-line information]. Available online at http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers through http://www.cancer.gov. Accessed May 2012.

Liu, X. et. al. (2011 February 13). KRAS Gene Mutation in Colorectal Cancer is Correlated with Increased Proliferation and Spontaneous Apoptosis. Medscape Today News from Am J Clin Pathol. v 135:245-252. [On-line information]. Available online at http://www.medscape.com/viewarticle/736647 through http://www.medscape.com. Accessed May 2012.

(Revised 2012 February 17). Lung Cancer (Non-Small Cell), How is non-small cell lung cancer diagnosed? American Cancer Society [On-line information]. Available online through http://www.cancer.org. Accessed May 2012.

(Revised 2012 January 25). How is colorectal cancer diagnosed? American Cancer Society [On-line information]. Available online through http://www.cancer.org. Accessed May 2012.

(Reviewed 2009 November). KRAS Mutation Analysis. Quest Diagnostics [On-line information]. Available online at http://www.questdiagnostics.com/testcenter/testguide.action?fn=Lung/TS_KRAS.htm through http://www.questdiagnostics.com. Accessed May 2012.

Chowdhuri, S. et. al. (2012 May 8). EGFR and KRAS Mutation Analysis in Cytologic Samples of Lung Adenocarcinoma Enabled by Laser Capture Microdissection. Medscape Today News from Modern Pathology. v 25(4):548-555 [On-line information]. Available online at http://www.medscape.com/viewarticle/763033 through http://www.medscape.com. Accessed May 2012.

(Reviewed Sept 7 2012) National Cancer Institute. Targeted Cancer Therapies. Available online at http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted through http://www.cancer.gov. Accessed September 2012.