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Lactate

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Also known as: Lactic Acid; L-Lactate; CSF Lactate
Formal name: Lactate

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Dugdale, D. (Updated 2013 May 5). Lactic acid test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003507.htm through http://www.nlm.nih.gov. Accessed October 2014.

Gunnerson, K. (Updated 2013 June 24). Lactic Acidosis. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/167027-overview through http://emedicine.medscape.com. Accessed October 2014.

(© 1995–2014). Lactate, Plasma. Mayo Clinic Mayo Medical Laboratory [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/8665 through http://www.mayomedicallaboratories.com. Accessed October 2014.

Lewis, J. (Revised 2013 February). Metabolic Acidosis. The Merck Manual Professional Edition [On-line information]. Available online through http://www.merckmanuals.com. Accessed October 2014.

Dietzen, D. (2012 August 3). Lactate and Lactic Acidemia. Clinical Chemistry Trainee Council Pearls of Laboratory Medicine [On-line information]. Available online through http://www.aacc.org. Accessed October 2014.

Couturier, M. et. al. (Updated 2014 March). Metabolic Acidosis. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/MetabolicAcidosis.html?client_ID=LTD#tabs=0. through http://www.arupconsult.com. Accessed October 2014.

Gaieski, D. et. al. (2013). Accuracy of Handheld Point-of-Care Fingertip Lactate Measurement in the Emergency Department. Medscape Multispecialty from Western J Emerg Med v14 (1):58-62. [On-line information]. Available online at http://www.medscape.com/viewarticle/780165 through http://www.medscape.com. Accessed October 2014.

Sources Used in Previous Reviews

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Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO. Pp. 527-528

Datta, V. Updated (2005 May 17). Lactic acid. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003507.htm.

Owens, T., Updated (2004 October 20). Lactic acidosis. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000391.htm.

(2002 January, Updated). Lactate (Liquid) Reagent Set. Pointe Scientific, Inc. [On-line Reagent Package Insert]. Available online at http://pointescientific.com/products/inserts/PI-L7596.pdf#search='lactate%20reagent%20blood%20test through http://pointescientific.com.

(© 2000). Simplified Reagent Handling LAC Lactate Ion. Beckman Coulter [On-line information]. Available online at http://www.beckman.com/literature/ClinDiag/GC9157GGLAC.pdf#search='Lactic%20acid%20reagent%20blood%20test through http://www.beckman.com.

Hall, K. and Zalman, B. (2005 June 15). Evaluation and Management of Apparent Life-Threatening Events in Children. American Family Physician [On-line journal]. Available online at http://www.aafp.org/afp/20050615/2301.html through http://www.aafp.org.

Parham, Sue (2005 March). In right setting, POC testing can be kid stuff. College of American Pathologists, CAP Today [On-line journal]. Available online at http://www.cap.org/apps/docs/cap_today/feature_stories/0305POC.html through http://www.cap.org.

(© 2005). Lactic Acid, Plasma. ARUP's User's Guide [On-line information]. Available online at http://www.aruplab.com/guides/ug/tests/0020045.jsp through http://www.aruplab.com.

(2001 October). Lactic Acid and Biopsy Tests. MDA Ask the Experts [On-line information]. Available online at http://www.mdausa.org/experts/question.cfm?id=2104&disease=97 through http://www.mdausa.org.

Hesterlee, S. (1999 October). Mitochondrial Disease In Perspective Symptoms, Diagnosis And Hope For The Future. MDA QUEST v6(5) [On-line publication]. Available online at http://www.mdausa.org/publications/Quest/q65mito.html through http://www.mdausa.org.

(2001 November). Facts about Mitochondrial Myopathies. MDA Publications [On-line information]. Available online at http://www.mdausa.org/publications/mitochondrial_myopathies.html through http://www.mdausa.org.

Westerblad, H. and Allen, D. (2002 December 18). Recent Advances in the Understanding of Skeletal Muscle Fatigue. Medscape, from Current Opinion in Rheumatology [On-line information]. Available online at http://www.medscape.com/viewarticle/444388 through http://www.medscape.com.

Nissl, J. (2004 October 28). Lactic Acid. WebMD Health Guide A-Z [On-line information]. Available online at http://my.webmd.com/hw/lab_tests/hw7871.asp through http://my.webmd.com.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp. 584-585.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp. 322.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp. 650-653.

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pp. 1068.

Karon, B. et. al. (2007 August 22). Comparison of Lactate Values Between Point-of-Care and Central Laboratory Analyzers. Medscape from Am J Clin Pathol. 2007;128(1):168-171 [On-line information]. Available online at http://www.medscape.com/viewarticle/559974 through http://www.medscape.com. Accessed on 11/23/08.

Van Voorhees, B. (2007 May 17, Updated). Lactic acid test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003507.htm. Accessed on 11/27/08.

Nicks, B. et. al. (2008 April 9, Updated). Lactic Acidosis. emedicine [On-line information]. Available online at http://www.emedicine.com/emerg/topic291.htm through http://www.emedicine.com. Accessed on 11/27/08.

(Updated March 27, 2007) Sharma S, Lactic Acidosis, eMedicine. Available online at http://emedicine.medscape.com/article/167027-overview through http://www.emedicine.com. Accessed February 2009.

Mizock B, Falk J. Lactic Acid in Critical Illness. Critical Care Medicine Vol. 20 No. 1 January, 1992.

Lactic acid test. MedlinePlus Medical Encylopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003507.htm. Accessed March 2011.

Glatter, R. and Winters, M. (2009 January 8). What Is the Clinical Utility of Obtaining Serum Lactate and Arterial Base Deficit Values in Patients With Early Signs of Sepsis and Septic Shock? Medscape Today. [On-line information]. Available online at http://www.medscape.com/viewarticle/585490 through http://www.medscape.com. Accessed March 2011.

Filbin, M. (Updated 2010 November 5). Septic Shock. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/786058-overview through http://emedicine.medscape.com. Accessed March 2011.

Boggs, W. (2010 June 17). Targeting Lactate Clearance Improves ICU Outcomes Medscape Today from Reuters Health Information [On-line information]. Available online at http://www.medscape.com/viewarticle/723725 through http://www.medscape.com. Accessed March 2011.

Nicks, B. et. al. (2010 April 29). Lactic Acidosis in Emergency Medicine. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/768159-overview through http://emedicine.medscape.com. Accessed March 2011.

(© 1995-2011). Unit Code 8657: Pyruvic Acid, Blood. MayoClinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8657 through http://www.mayomedicallaboratories.com. Accessed March 2011.

(© 1995-2011). Unit Code 8665: Lactate, Plasma. MayoClinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/8665 through http://www.mayomedicallaboratories.com. Accessed March 2011.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 601-602.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 650-653.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC, Pg 232.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 163,197.

Debray, FG. Diagnostic Accuracy of Blood Lactate-to-Pyruvate Molar Ratio in the Differential Diagnosis of Congenital Lactic Acidosis. Clin Chem, May 2007 53: 917-921.

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(July 2010) Shaprio N, et al. The Feasibility and Accuracy of Point-of-Care Lactate Measurement in Emergency Department Patients with Suspected Infection. The Journal of Emergency Medicine. Volume 39, Issue 1, July 2010, Pp 89-94.