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Levetiracetam

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Also known as: [May be referred to by brand name (see MedlinePlus Drug Information)]
Formal name: Levetiracetam

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2017 review performed by Charbel Abou-Diwan, PhD, DABCC, FACB.

Patsalos PN, Berry DJ, Bourgeois BF, et al. Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008 Jul;49(7):1239-1276.

Leppik, I. E. et al. 2002. Effective levetiracetam doses and serum concentrations: Age effects. Epilepsia 43 (Suppl 7):240.

Shih JJ, Whitlock JB, et al. Epilepsy treatment in adults and adolescents: Expert opinion, 2016 Epilepsy & Behavior 2017, Feb 22.

Naik GS, Kodagali R, et al. Therapeutic Drug Monitoring of Levetiracetam and Lamotrigine: Is There a Need? Ther Drug Monit Volume 37, Number 4, August 2015.

Stepanova D, Beran RG. Measurement of levetiracetam drug levels to assist with seizure control and monitoring of drug interactions with other anti-epileptic medications (AEMs). Seizure 23 (2014) 371–376.

Sources Used in Previous Reviews

Cavazos, J. (Updated 2013 March 11). Epilepsy and Seizures. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1184846-overview. Accessed April 2013.

(© 1995-2013). Levetiracetam, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/83140. Accessed April 2013.

Ochoa, J. and Riche, W. (Updated 2012 October 25). Antiepileptic Drugs. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1187334-overview. Accessed April 2013.

Johnson-Davis, K. (Reviewed 2013 February). Seizure Disorders – Epilepsy. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/SeizureDis.html?client_ID=LTD#tabs=0. Accessed April 2013.

(Revised 2009 September 1) Levetiracetam. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/meds/a699059.html. Accessed April 2013.

Rosenow, F. (2012). Lamotrigine Compared With Levetiracetam in the Initial 26 Weeks of Monotherapy for Focal and Generalised Epilepsy. Medscape News from J Neurol Neurosurg Psychiatry. 2012;83(11):1093-1098. [On-line information]. Available online at http://www.medscape.com/viewarticle/772590. Accessed April 2013.

Ha, H. and Bellanger, R. (2013). Epilepsy: Treatment and Management. Medscape Today News from US Pharmacist. 2013;38(1):35-39 [On-line information]. Available online at http://www.medscape.com/viewarticle/779381. Accessed April 2013.

Buck, M. (2012). Recent Literature on Pediatric Antiepileptic Drugs. Medscape Today News from Pediatr Pharm. 2012;18(12) [On-line information]. Available online at http://www.medscape.com/viewarticle/781121. Accessed April 2013.

Krasowski, M. (2010 May 11). Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications. Pharmaceuticals 2010, 3(6), 1909-1935. [On-line information]. Available online at http://www.mdpi.com/1424-8247/3/6/1909. Accessed April 2013.

Krishna, K. et. al. (2011 October). Levetiracetam. JAPI v 59 [On-line information]. PDF available for download at http://www.japi.org/october_2011/09_dr_levetiracetam.pdf. Accessed April 2013.

(Revised 2013 February). LevETIRAcetam. Merck Manual for Healthcare Professionals [On-line information]. Available online at http://www.merckmanuals.com/professional/lexicomp/levetiracetam.html. Accessed April 2013.

Buck, M. (2012 December 12). Recent Literature on Pediatric Antiepileptic Drugs. Pediatric Pharmacotherapy. A Monthly Newsletter for Health Care Professionals from the University of Virginia Children's Hospital v 18 (12) [On-line information]. PDF available for download through http://www.medicine.virginia.edu. Accessed April 2013.

Groot, M. et. al. (2012). Epilepsy in Patients With a Brain Tumour, Focal Epilepsy Requires Focused Treatment. Brain. V 135(4):1002-1016. [On-line information]. Available online at http://www.medscape.com/viewarticle/763947_1. Accessed April 2013.

St. Louis E. Monitoring Antiepileptic Drugs: A Level-headed Approach. Curr Neuropharmacol. 2009 June; 7(2): 115–119. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730002/. Accessed April 2013.

Krasowski M. Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications. Pharmaceuticals (Basel). 2010 June 11; 3(6): 1909–1935. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904466/#R7. Accessed April 2013.