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Lp-PLA2

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Also known as: LpPLA2; Lp-PLA2 Activity Test; Platelet-activating Factor Acetylhydrolase; PAF-AH; PLAC
Formal name: Lipoprotein-associated Phospholipase A2

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

White H, et. al. Changes in Lipoprotein‐Associated Phospholipase A2 Activity Predict Coronary Events and Partly Account for the Treatment Effect of Pravastatin: Results From the Long‐term Intervention with Pravastatin in Ischemic Disease Study. J Am Heart Assoc. 2013 October; 2(5): e000360. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835245/ through http://www.ncbi.nlm.nih.gov. Accessed December 2013.

O'Riordan, M. (2010 April 29). Modest association between Lp-PLA2 and coronary heart disease. Medscape Multispecialty [On-line information]. Available online at http://www.medscape.com/viewarticle/790614 through http://www.medscape.com. Accessed March 2014.

(© 1995-2014). Lipoprotein Associated Phospholipase A2 (PLAC). Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/57353 through http://www.mayomedicallaboratories.com. Accessed March 2014.

Sultan, S. and Elkind, M. (Updated 2013 October 31). Genetic and Inflammatory Mechanisms in Stroke. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1163331-overview#showall through http://emedicine.medscape.com. Accessed March 2014.

(2013 November). Lipoprotein-Associated Phospholipase A2: How Effective as a Risk Marker of Cardiovascular Disease and as a Therapeutic Target? BioPortfolio [On-line information]. Available online at http://www.bioportfolio.com/resources/pmarticle/178617/Lipoprotein-Associated-Phospholipase-A2-How-Effective-as-a-Risk-Marker-of-Cardiovascular.html through http://www.bioportfolio.com. Accessed November 2013.

Delgado, J. et. al. (Updated 2014 March). Cardiovascular Disease (Non-traditional Risk Markers) - Risk Markers - CVD (Non-traditional). ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/CVDRiskMarkerNontrad.html?client_ID=LTD through http://www.arupconsult.com. Accessed March 2014.

Zalewski, A. et. al. (2006 September). Lp-PLA2: A New Kid on the Block. Clinical Chemistry v 52 (9) 1645-1650. [On-line information]. Available online at http://www.clinchem.org/content/52/9/1645.long through http://www.clinchem.org. Accessed March 2014.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pg 621.

(©2012) American Association of Clinical Endocrinologists' Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis. Available online at https://www.aace.com/files/lipid-guidelines.pdf through https://www.aace.com. Accessed March 2014.

Maiolino G, et al (October 31, 2013). Lipoprotein-Associated Phospholipase A2 Activity Predicts Cardiovascular Events in High Risk Coronary Artery Disease Patients. PLoS One. 2012; 7(10): e48171. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485195/ through http://www.ncbi.nlm.nih.gov. Accessed March 2014.

(April 26 2012) New Clinical Endocrinology Guidelines Support Lp-PLA2 Measurement For Risk Assessment of Coronary Artery Disease. Press Release, Reuters. Available online at http://uk.reuters.com/article/2012/04/26/idUS191175+26-Apr-2012+PRN20120426 through http://uk.reuters.com. Accessed March 2014.

Sources Used in Previous Reviews

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 682-683.

O'Riordan, M. (2008 February 27). Elevated Lp-PLA2 Levels Predict Incident CHD Independent of Traditional Risk Factors. Medscape Today from Heartwire [On-line information]. Available online at http://www.medscape.com/viewarticle/570751 through http://www.medscape.com. Accessed May 2009.

Boero, L. et. al. (2009 April 01). Alterations in Biomarkers of Cardiovascular Disease in Active Acromegaly. Medscape Today from Clinical Endocrinology [On-line information]. Available online at http://www.medscape.com/viewarticle/586806 through http://www.medscape.com. Accessed May 2009.

(Updated 2009 May). The Physician's Guide to Laboratory Test Selection and Interpretation, Cardiovascular Disease (Non-traditional Risk Markers) - Risk Markers - CVD (Non-traditional). ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/CardiacDz/CVDRiskMarkerNontrad.html?client_ID=LTD through http://www.arupconsult.com. Accessed May 2009.

(2007 July). Lipoprotein-Associated Phospholipase A2 (PLAC™). ARUP Technical Bulletin [On-line information]. Available online through http://www.aruplab.com . Accessed May 2009.

(Reviewed 2007 November). Lp-PLA2 Test Summary. Quest Diagnostics Interpretive Guide [On-line information]. Available online at http://www.questdiagnostics.com/hcp/intguide/jsp/showintguidepage.jsp?fn=TS_Lp-PLA2.htm through http://www.questdiagnostics.com. Accessed May 2009.

Elkind, M. et. al. (2006 June 14). Genetic and Inflammatory Mechanisms in Stroke. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/1163331-overview through http://emedicine.medscape.com. Accessed May 2009.

Lusky, K. (2008 July). New clue for predicting stroke risk: Lp-PLA2. CAP Today [On-line information]. Available online through http://www.cap.org. Accessed May 2009.

Persson, M. et. al. (2007 June). Elevated Lp-PLA2 Levels Add Prognostic Information to the Metabolic Syndrome on Incidence of Cardiovascular Events Among Middle-Aged Nondiabetic Subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:1411 [On-line information]. Available online at http://atvb.ahajournals.org/cgi/content/full/27/6/1411 through http://atvb.ahajournals.org. Accessed May 2009.

What are the Types of Stroke? American Stroke Association [On-line information]. Available online at http://www.strokeassociation.org/presenter.jhtml?identifier=1014 through http://www.strokeassociation.org. Accessed May 2009.