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Mononucleosis (Mono) Test

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Also known as: Mononucleosis Spot Test; Mononuclear Heterophile Test; Heterophile Antibody Test; Monospot
Formal name: Heterophile Antibody Titer

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

(Jan 2014) Centers for Disease Control and Prevention. About Infectious Mononucleosis. Available online at http://www.cdc.gov/epstein-barr/about-mono.html. Accessed June 13, 2016.

(Mar 2011) Cohen, J. et al. Blood. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112034/. Accessed June 14, 2016.

(Oct 2015) Cunha, B. Medscape. Infectious Mononucleosis Workup. Available online at http://emedicine.medscape.com/article/222040-workup. Accessed June 13, 2016.

(Mar 2015) Womack, J. and Jimenez, M. American Association of Family Physicians. Common Questions about Infectious Mononucleosis. Available online at http://www.aafp.org/afp/2015/0315/p372.html. Accessed June 13, 2016.

Sources Used in Previous Reviews

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO. Pp 594-595.

Corbett, JV. Laboratory Tests & Diagnostic Procedures with Nursing Diagnoses, 4th ed. Stamford, Conn.: Appleton & Lang, 1996. Pp. 373-374.

Ebell, M. (2004 October 1). Epstein-Barr Virus Infectious Mononucleosis. American Family Physician [On-line journal]. Available online at http://www.aafp.org/afp/20041001/1279.html.

Schmid, S., Leader Herpesvirus Group (2005 September 13, Updated). Epstein-Barr Virus and Infectious Mononucleosis. CDC, National Center for Infectious Diseases [On-line information]. Available online at http://www.cdc.gov/ncidod/diseases/ebv.htm.

National Center for Infectious Diseases. Epstein-Barr Virus and Infectious Mononucleosis. Available online at http://www.cdc.gov/ncidod/diseases/ebv.htm.

Nebraska Health and Human Services System. Infectious Mononucleosis (Mono) Disease Fact Sheet. Available online at http://www.hhs.state.ne.us/epi/epimono.htm.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 662-663.

Cunha, B. (Updated 2008 October 17). Infectious Mononucleosis. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/222040-overview. Accessed May 2009.

Omori, M. (Updated 2009 April 02). Mononucleosis. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/784513-overview. Accessed May 2009.

Smith, D. S. (Updated 2008 September 3). Mononucleosis. MedlinePlus Medical Encyclopedia eMedicine [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000591.htm. Accessed May 2009.

Smith, D. S. (Updated 2008 September 3). Mononucleosis spot test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003454.htm. Accessed May 2009.

Vorvick, L. (2012 May 15). Mononucleosis spot test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003454.htm. Accessed November 2012.

Omori, M. (Updated 2012 May 23). Mononucleosis in Emergency Medicine. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/784513-overview. Accessed November 2012.

Cunha, B. and Levy, C. (Updated 2011 September 21). Infectious Mononucleosis. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/222040-overview. Accessed November 2012.

Mayo Clinic Staff (2010 June 26). Mononucleosis. Mayo Clinic [On-line information]. Available online at http://www.mayoclinic.com/print/mononucleosis/DS00352/DSECTION=all&METHOD=print. Accessed November 2012.

Vorvick, L. (2012 May 15). Mononucleosis MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000591.htm. Accessed November 2012.

Hirsch, L. (Reviewed 2011 January). Mononucleosis. Nemours Foundation [On-line information]. Available online at http://kidshealth.org/parent/infections/common/mono.html. Accessed November 2012.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 683-684.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds (2005). Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp1046-1048.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Pp 555-556.