Proceeds from website advertising help sustain Lab Tests Online. AACC is a not-for-profit organization and does not endorse non-AACC products and services.

Platelet Function Tests

Print this article
Share this page:
Also known as: Platelet Aggregation Studies; PFT; Platelet Function Assay; PFA
Formal name: Platelet Function Tests

Article Sources

« Return to Related Pages

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2011, 805-816.

Wintrobe's Clinical Hematology. 12th ed. Greer J, Foerster J, Rodgers G, Paraskevas F, Glader B, Arber D, Means R, eds. Philadelphia, PA: Lippincott Williams & Wilkins: 2009, Pp 1362-1363.

(©2014) Platelet Function Disorders. Written by David Page, Reviewed by Sara J. Israels, M.D. FRCP(C). Canadian Hemophilia Society. Available online at http://www.hemophilia.ca/en/bleeding-disorders/platelet-function-disorders/introduction/ through http://www.hemophilia.ca. Accessed February 2014.

(August 28, 2012) Sue Hughes. Should Platelet Function Be Measured? New Data. Medscape News. Available online at http://www.medscape.com/viewarticle/769925 through http://www.medscape.com. Accessed February 2014.

(October 08, 2013) Michael O'Riordan. Platelet-Function Testing Might Benefit Select PCI Patients, Says Expert Panel. Medscape News. Available online at http://www.medscape.com/viewarticle/812254 through http://www.medscape.com. Accessed February 2014.

Gorelick P, Farooq M. Advances in Our Understanding of "Resistance" to Antiplatelet Agents for Prevention of Ischemic Stroke. Stroke Res Treat. 2013; 2013: 727842. Published online 2013 July 14 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725785/ through http://www.ncbi.nlm.nih.gov. Accessed February 2014.

(December 07, 2012) Lisa Nainggolan. Pharmacologists Question Aspirin Resistance. Medscape News. Available online at http://www.medscape.com/viewarticle/775844 through http://www.medscape.com. Accessed February 2014.

Brad S. Karon, MD, PhD and Elizabeth Jaben, MD. Platelet Function, Laboratory Methods for Evaluating Effectiveness of Anti-platelet Therapy. Clinical Laboratory News April 2011: Volume 37, Number 4. Available online at http://www.aacc.org/publications/cln/2011/April/Pages/PlateletFunction.aspx# through http://www.aacc.org. Accessed February 2014.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber’s Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby’s Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Bleeding Time. AccessMed Health Information Library [On-line information]. Available online at http://www.hendrickhealth.org/healthy/000209.htm through http://www.hendrickhealth.org.

Elstrom, R. (2001 October 28, Updated). Platelet aggregation test. MEDLINEplus Health Information, Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003669.htm.

Menta, S. (1999 Spring). The Coagulation Cascade. Physiology Disorders Evaluation, College of Medicine, Univ of Florida [On-line information]. Available online at http://www.medinfo.ufl.edu/year2/coag/title.html through http://www.medinfo.ufl.edu.

Platelet Function Analyzer (PFA)-100 – FAQ. Florida Hospital Cancer Institute, Clinical and Research Laboratories [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/faq/pfa-faq.htm through http://www.fhci-labs.com.

Kottke-Marchant, K. and Aller, R. (2003 January). Toward multi-functional analyzers. College of American Pathologists, January 2003 Survey of instruments [On-line information]. Available online at http://www.cap.org/apps/docs/cap_today/surveys/coagSurvIntro.html through http://www.cap.org.

Corcoran, G. and Kottke-Marchant, K. (2002 June). Chasing after the causes of platelet disorders. College of American Pathologists, Feature Story [On-line article]. Available online at http://www.cap.org/apps/docs/cap_today/feature_stories/platelet_disorders_feature.html through http://www.cap.org.

What is Idiopathic Thrombocytopenic Purpura? NHLBI, Diseases and Conditions Index [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_WhatIs.html through http://www.nhlbi.nih.gov.

What is von Willebrand Disease? NHLBI, Diseases and Conditions Index [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/vWD/vWD_WhatIs.html through http://www.nhlbi.nih.gov.

Von Willebrand Disease. NHF [On-line information]. Available online at http://www.hemophilia.org/bdi/bdi_types3.htm through http://www.hemophilia.org.

Hemostasis. Merck Manual of Diagnosis and Therapy [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual/section11/chapter131/131b.jsp through http://www.merck.com.

Bleeding Disorders. The Merck Manual of Medical Information-Home Edition, Section 14. Blood Disorders, Chapter 155 [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual_home/sec14/155.jsp through http://www.merck.com.

Cortese Hassett, A. (2002). Platelet Function Testing. Transfusion Medicine Update, The Institute for Transfusion Medicine, Issue #5 [On-line information]. Available online at http://www.itxm.org/TMU2002/Issue5.htm through http://www.itxm.org.

Lee, D. (2000 July 24). Platelet Aggregometry. Stanford Interventional Cardiology [On-line information]. Previously available online at http://cvmed.stanford.edu/interventional/aggregometry.htm.

Coagulation Test Panels. Clinical and Research Laboratories, Florida Hospital Cancer Institute [On-line information]. Available online at http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm through http://www.fhci-labs.com.

Carville, D. and Guyer, K. (2000 September). Hemostasis testing: past, present, and Future. IVD Technology Magazine, medical devicelink [On-line article]. Available online at http://www.devicelink.com/ivdt/archive/00/09/005.html through http://www.devicelink.com.

Locke, J. (2001 October). Issues in Platelet Function Testing. Clinical Laboratory Strategies [On-line AACC Newsletter]. Prepublication version available from Jalane at jtechwriter@yahoo.com.

Wuillemin, W., et.al. (2002). Evaluation of a Platelet Function Analyser (PFA-100Ò) in patients with a bleeding tendency. Swiss Med Wkly 132:443-448 [On-line journal]. PDF available for download at http://www.smw.ch/pdf200x/2002/31/smw-10039.PDF through http://www.smw.ch.

SE Lind. The bleeding time does not predict surgical bleeding. Blood, Jun 1991; 77: 2547 - 2552.

RPC RODGERS, J LEVIN, and SE LIND. Bleeding Time Revisited Blood, May 1992; 79: 2495 - 2497.

Hankey, G. and Eikelboom, J. (2004 February 28) Aspirin resistance. BMJ 2004;328:477-479 [On-line journal]. Available online at http://bmj.bmjjournals.com/cgi/content/full/328/7438/477 through http://bmj.bmjjournals.com.

Peterson, P. (2005 October). Aspirin Resistance: Fact and Fiction. Medscape Conference Coverage, based on selected sessions at the: Pathology Today: American Society for Clinical Pathology 2005 Annual Meeting [On-line CME/CMLE]. Available online at http://www.medscape.com/viewarticle/518858 through http://www.medscape.com.

Eikelboom, J. et. al. (2005 July 11). Aspirin Resistance and Its Implications in Clinical Practice. Medscape General Medicine 2005;7(3):76 [On-line information]. Available online at http://www.medscape.com/viewarticle/506101 through http://www.medscape.com.

(2004 September 3). Accumetrics VerifyNow-Aspirin Assay (Formerly Ultegra RPFA-ASA). FDA 510(k) Summary [On-line information]. PDF available for download at http://www.fda.gov/cdrh/pdf4/k042423.pdf through http://www.fda.gov.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 169-171, 728-729.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 235-237.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 862-867.

Dugdale, D. and Chen, Y. (Updated 2009 March 02). Platelet aggregation test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003669.htm. Accessed September 2009.

(Updated 2008 December). Functional Platelet Disorders. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/FxPlateletDisorders.html# through http://www.arupconsult.com. Accessed September 2009.

Ang, L. and Mahmud, E. (2009 January 15). Monitoring Oral Antiplatelet Therapy: Is It Justified? Medscape from Therapeutic Advances in Cardiovascular Disease. [On-line information]. Available online at http://www.medscape.com/viewarticle/584888 through http://www.medscape.com. Accessed September 2009.

Gurbel, P. et. al. (2007 November 05). Platelet Function Monitoring in Patients With Coronary Artery Disease. Medscape from Journal of the American Journal of Cardiology. [On-line information]. Available online at http://www.medscape.com/viewarticle/564963 through http://www.medscape.com. Accessed September 2009.

Hughes, S. (2009 March 28). ACC 2009: Evidence Growing for Personalized Antiplatelet Therapy. Medscape from Heartwire [On-line information]. Available online at http://www.medscape.com/viewarticle/590292 through http://www.medscape.com. Accessed September 2009.

Stasik, C. (2006 August 1). Principles, Indications, and Limitations of the Platelet Function Analyzer. CAP NewsPath [On-line information]. Available online through http://www.cap.org. Accessed September 2009.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson RA and Pincus MR, eds. Philadelphia: 2007, Pp 757-765.

(Published 17 January 2008) Krasopoulos G, Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ, doi: 10.1136/bmj.39430.529549.BE, Available online at http://www.bmj.com/cgi/content/full/bmj.39430.529549.BEv1 through http://www.bmj.com. Accessed September 2009.

Harrison's Principles of Internal Medicine. 16th ed. Kasper D, Braunwald E, Fauci A, Hauser S, Longo D, Jameson JL, eds. McGraw-Hill, 2005, Pp 676-678.