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Platelet Function Tests

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Also known as: Platelet Aggregation Studies; PFT; Platelet Function Assay; PFA
Formal name: Platelet Function Tests

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2017 review performed by Nicole Ziegler, MT (ASCP) and the Editorial Review Board.

Kottke-Marchant, Kandice (©2016) An Algorithmic Approach to Hemostasis Testing Second Edition: College of American Pathologists (CAP) Press, Northfield, IL. Pp 17-32, 99-120

Chandler, W.L. Emergency assessment of hemostasis in the bleeding patient. Int J Lab Hematol. 2013; 35:339-343. Available online at Accessed on 4/27/17 Accessed on 6/2/2017.

Harrison, P and Lordkipanidze, M. Testing Platelet Function. Hematol Onc Clin N Am. 2013; 27:411-441.

Breet NJ, van Werkum, JW, Bouman HJ, et al. Comparison of six major platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA 2010; 303(8): 849-56. Available online at Abstract accessed 6/2/2017.

Breet NJ, van Werkum JW, Bouman HJ, et al. High on-aspirin platelet reactivity as measured with aggregation-based, cyclooxygenase-1 inhibition sensitive platelet function tests is associated with the occurrence of atherothrombotic events. J Thromb Haemost 2010;8(10):2140-8. Available online at Accessed 4/27/17.

Paniccia R, Priora R, Alessandrello A, et al. Platelet function tests: a comparative review. Vascul Health Risk Manage 2015; 11:133-148.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber’s Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby’s Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Bleeding Time. AccessMed Health Information Library [On-line information]. Available online at

Elstrom, R. (2001 October 28, Updated). Platelet aggregation test. MedlinePlus Health Information, Medical Encyclopedia [On-line information]. Available online at

Menta, S. (1999 Spring). The Coagulation Cascade. Physiology Disorders Evaluation, College of Medicine, Univ of Florida [On-line information]. Available online at

Platelet Function Analyzer (PFA)-100 – FAQ. Florida Hospital Cancer Institute, Clinical and Research Laboratories [On-line information]. Available online at

Kottke-Marchant, K. and Aller, R. (2003 January). Toward multi-functional analyzers. College of American Pathologists, January 2003 Survey of instruments [On-line information]. Available online at

Corcoran, G. and Kottke-Marchant, K. (2002 June). Chasing after the causes of platelet disorders. College of American Pathologists, Feature Story [On-line article]. Available online at

What is Idiopathic Thrombocytopenic Purpura? NHLBI, Diseases and Conditions Index [On-line information]. Available online at

What is von Willebrand Disease? NHLBI, Diseases and Conditions Index [On-line information]. Available online at

Von Willebrand Disease. NHF [On-line information]. Available online at

Hemostasis. Merck Manual of Diagnosis and Therapy [On-line information]. Available online at

Bleeding Disorders. The Merck Manual of Medical Information-Home Edition, Section 14. Blood Disorders, Chapter 155 [On-line information]. Available online at

Cortese Hassett, A. (2002). Platelet Function Testing. Transfusion Medicine Update, The Institute for Transfusion Medicine, Issue #5 [On-line information]. Available online at

Lee, D. (2000 July 24). Platelet Aggregometry. Stanford Interventional Cardiology [On-line information]. Previously available online at

Coagulation Test Panels. Clinical and Research Laboratories, Florida Hospital Cancer Institute [On-line information]. Available online at

Carville, D. and Guyer, K. (2000 September). Hemostasis testing: past, present, and Future. IVD Technology Magazine, medical devicelink [On-line article]. Available online at

Locke, J. (2001 October). Issues in Platelet Function Testing. Clinical Laboratory Strategies [On-line AACC Newsletter]. Prepublication version available from Jalane at

Wuillemin, W., (2002). Evaluation of a Platelet Function Analyser (PFA-100Ò) in patients with a bleeding tendency. Swiss Med Wkly 132:443-448 [On-line journal]. PDF available for download at

SE Lind. The bleeding time does not predict surgical bleeding. Blood, Jun 1991; 77: 2547 - 2552.

RPC RODGERS, J LEVIN, and SE LIND. Bleeding Time Revisited Blood, May 1992; 79: 2495 - 2497.

Hankey, G. and Eikelboom, J. (2004 February 28) Aspirin resistance. BMJ 2004;328:477-479 [On-line journal]. Available online at

Peterson, P. (2005 October). Aspirin Resistance: Fact and Fiction. Medscape Conference Coverage, based on selected sessions at the: Pathology Today: American Society for Clinical Pathology 2005 Annual Meeting [On-line CME/CMLE]. Available online at

Eikelboom, J. et. al. (2005 July 11). Aspirin Resistance and Its Implications in Clinical Practice. Medscape General Medicine 2005;7(3):76 [On-line information]. Available online at

(2004 September 3). Accumetrics VerifyNow-Aspirin Assay (Formerly Ultegra RPFA-ASA). FDA 510(k) Summary [On-line information]. PDF available for download at

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 169-171, 728-729.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 235-237.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 862-867.

Dugdale, D. and Chen, Y. (Updated 2009 March 02). Platelet aggregation test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at Accessed September 2009.

(Updated 2008 December). Functional Platelet Disorders. ARUP Consult [On-line information]. Available online at Accessed September 2009.

Ang, L. and Mahmud, E. (2009 January 15). Monitoring Oral Antiplatelet Therapy: Is It Justified? Medscape from Therapeutic Advances in Cardiovascular Disease. [On-line information]. Available online at Accessed September 2009.

Gurbel, P. et. al. (2007 November 05). Platelet Function Monitoring in Patients With Coronary Artery Disease. Medscape from Journal of the American Journal of Cardiology. [On-line information]. Available online at Accessed September 2009.

Hughes, S. (2009 March 28). ACC 2009: Evidence Growing for Personalized Antiplatelet Therapy. Medscape from Heartwire [On-line information]. Available online at Accessed September 2009.

Stasik, C. (2006 August 1). Principles, Indications, and Limitations of the Platelet Function Analyzer. CAP NewsPath [On-line information]. Available online through Accessed September 2009.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson RA and Pincus MR, eds. Philadelphia: 2007, Pp 757-765.

(Published 17 January 2008) Krasopoulos G, Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ, doi: 10.1136/bmj.39430.529549.BE, Available online at Accessed September 2009.

Harrison's Principles of Internal Medicine. 16th ed. Kasper D, Braunwald E, Fauci A, Hauser S, Longo D, Jameson JL, eds. McGraw-Hill, 2005, Pp 676-678.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2011, 805-816.

Wintrobe's Clinical Hematology. 12th ed. Greer J, Foerster J, Rodgers G, Paraskevas F, Glader B, Arber D, Means R, eds. Philadelphia, PA: Lippincott Williams & Wilkins: 2009, Pp 1362-1363.

(©2014) Platelet Function Disorders. Written by David Page, Reviewed by Sara J. Israels, M.D. FRCP(C). Canadian Hemophilia Society. Available online at Accessed February 2014.

(August 28, 2012) Sue Hughes. Should Platelet Function Be Measured? New Data. Medscape News. Available online at Accessed February 2014.

(October 08, 2013) Michael O'Riordan. Platelet-Function Testing Might Benefit Select PCI Patients, Says Expert Panel. Medscape News. Available online at Accessed February 2014.

Gorelick P, Farooq M. Advances in Our Understanding of "Resistance" to Antiplatelet Agents for Prevention of Ischemic Stroke. Stroke Res Treat. 2013; 2013: 727842. Published online 2013 July 14 at Accessed February 2014.

(December 07, 2012) Lisa Nainggolan. Pharmacologists Question Aspirin Resistance. Medscape News. Available online at Accessed February 2014.

Brad S. Karon, MD, PhD and Elizabeth Jaben, MD. Platelet Function, Laboratory Methods for Evaluating Effectiveness of Anti-platelet Therapy. Clinical Laboratory News April 2011: Volume 37, Number 4. Available online at Accessed February 2014.