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PML-RARA

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Also known as: Promyelocytic Leukemia/Retinoic Acid Receptor Alpha [PML-RARA t(15;17)(q22;q12)]; Acute Promyelocytic Leukemia; AML-M3
Formal name: [PML-RARA t(15;17)]

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

2017 review performed by Omar Ramadan, PhD, MSc, MT (ASCPi) and the Lab Tests Online Editorial Review Board.

Hudnall, S. David. Hematology: A Pathophysiologic Approach. Mosby, 2012. The Mosby Physiology Monograph Series. EBSCOhost. Pg 88. Accessed on 03/19/2017@18:56 through Sentara Knowledge Online Resources (SKOR).

De Angelis F, Breccia M. Molecular Monitoring as a Path to Cure Acute Promyelocytic Leukemia. Rare Cancers Ther (2015) 3:119–132.

Lo-Coco F, Hasan SK. Understanding the molecular pathogenesis of acute promyelocytic leukemia. Best Pract Res Clin Haematol. 2014 Mar;27(1):3-9.

Bullinger L, Döhner 1, Döhner H. Genomics of Acute Myeloid Leukemia Diagnosis and Pathways. J Clin Oncol. 2017 Mar 20;35(9):934-946.

Grimwade D, Jovanovic JV, Hills RK. Can we say farewell to monitoring minimal residual disease in acute promyelocytic leukaemia? Best Pract Res Clin Haematol. 2014 Mar;27(1):53-61.

Chendamarai E, Balasubramanian P, George B, et al. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9.

Levine K, DeBlasio A, Miller WH Jr. Molecular diagnosis and monitoring of acute promyelocytic leukemia treated with retinoic acid. Leukemia. 1994 Apr;8 Suppl 1:S116-20.

Lengfelder E, Lo-Coco F, Ades L, et al. Arsenic trioxide-based therapy of relapsed acute promyelocytic leukemia: registry results from the European LeukemiaNet. Leukemia. 2015 May;29(5):1084-91.

Burnett AK, Hills RK, Grimwade D, et al. Inclusion of chemotherapy in addition to anthracycline in the treatment of acute promyelocytic leukaemia does not improve outcomes: results of the MRC AML15 trial.

Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013 Jul 11;369(2):111-21.

Jovanovic JV, Rennie K, Culligan D, et al. Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia. Front Oncol. 2011 Oct 25;1:35.

Sources Used in Previous Reviews

Seiter, K. (Updated 2012 March 9). Acute Myelogenous Leukemia. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/197802-overview#showall. Accessed May 2013.

Yang, J. and Schiffer, C. (2012). Genetic Biomarkers in Acute Myeloid Leukemia. Medscape Today News from Expert Rev Hematol. 2012;5(4):395-407. [On-line information]. Available online at http://www.medscape.com/viewarticle/771810. Accessed May 2013.

Mason, J. and Griffiths, M. (2012). Molecular Diagnosis of Leukemia. Medscape Today News from Expert Rev Mol Diagn. 2012;12(5):511-526. [On-line information]. Available online at http://www.medscape.com/viewarticle/766770. Accessed May 2013.

Kelley, T. and South, S. (2013 March). Acute Myeloid Leukemia – AML. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/AML.html?client_ID=LTD. Accessed May 2013.

(© 1995–2013). PML/RARA Quantitative, PCR. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-info/hematology/catalog/Overview/84114. Accessed May 2013.

(Reviewed 2011 April). Acute promyelocytic leukemia. Genetics Home Reference [On-line information]. Available online at http://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia. Accessed April 2013.

(Reviewed 2011 April). RARA. Genetics Home Reference [On-line information]. Available online at http://ghr.nlm.nih.gov/gene/RARA. Accessed April 2013.

Kelley, T. and Schumacher, J. (2012 August). PML-RARA , t(15;17) Quantitation by RT-PCR ARUP. ARUP Laboratories [On-line information]. PDF available for download at http://www.aruplab.com/Testing-Information/resources/TechnicalBulletins/PML-RARAt%2815;17%29QuantitationbyRT-PCR.pdf. Accessed April 2013.

VanderWalde, A. and Vora, N. (2012 June 18). Genetics of Acute Myeloid Leukemia Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1936033-overview. Accessed April 2013.

Kotiah, S. and Besa, E. (Updated 2011 August 2). Acute Promyelocytic Leukemia Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1495306-overview#showall. Accessed April 2013.

Polampalli, S., et. al. (2011) Role of RT-PCR and FISH in diagnosis and monitoring of acute promyelocytic leukemia. Indian J Cancer v 48:60-7. Available online through http://www.indianjcancer.com. Accessed May 2013.

Nasr, R. Et. al. (2009) Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure. Clin Cancer Res v 15:6321-6326. [On-line information]. Available online at http://clincancerres.aacrjournals.org/content/15/20/6321.full. Accessed April 2013.

Ommen, H. et. al. (2010 January 14). Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias. Blood v 115 (2) 198-205 [On-line information]. Available online at http://bloodjournal.hematologylibrary.org/content/115/2/198.full. Accessed April 2013.

(Reviewed 2011 December). PML/RARA t(15;17) Translocation, FISH and Quantitative Real-Time PCR. Quest Diagnostics [On-line information]. Available online at http://www.questdiagnostics.com/testcenter/testguide.action?dc=TH_PML_RARA. Accessed May 2013.