1. My father has been diagnosed with early onset Alzheimer disease (AD3). Can my doctor tell if my father has a genetic mutation without a blood test?
No, the symptoms for AD3, sporadic early onset AD, and late onset AD are the same except for the age of onset. You cannot tell whether someone has a genetic mutation just by looking at their perceived abnormal daily living activities. If there is a strong family history of early onset AD, especially if another family member has been diagnosed with a genetic mutation, your doctor may suspect a genetic problem that may be confirmed by a blood test.
2. Are there any other genetic tests that will diagnose AD?
The other genes that have mutations associated with AD3 are PSEN2 and APP (amyloid precursor protein). Testing is available, but it should be noted that these gene mutations are very rare and have only been identified in a very small number of specific family lines.
This article was last reviewed on March 14, 2014. | This article was last modified on March 26, 2014.
The review date indicates when the article was last reviewed from beginning to end to ensure that it reflects the most current science. A review may not require any modifications to the article, so the two dates may not always agree.
The modified date indicates that one or more changes were made to the article. Such changes may or may not result from a full review of the article, so the two dates may not always agree.